基于硅烷化的单官能团仲醇动力学拆分。
Silylation-based kinetic resolution of monofunctional secondary alcohols.
机构信息
Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, GSRC 109, Columbia, South Carolina 29208, USA.
出版信息
Org Lett. 2011 Aug 5;13(15):3794-7. doi: 10.1021/ol2012617. Epub 2011 Jun 29.
PMID:21714486
Abstract
The nucleophilic small molecule catalyst (-)-tetramisole was found to catalyze the kinetic resolution of monofunctional secondary alcohols via enantioselective silylation. Optimization of this new methodology allows for selectivity factors up to 25 utilizing commercially available reagents and mild reaction conditions.
摘要
手性小分子催化剂(-)-四咪唑被发现可以通过对映选择性硅烷化来催化单官能仲醇的动力学拆分。该新方法的优化可以使用商业可得的试剂和温和的反应条件，实现高达 25 的选择性因子。
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