Koelsch Stefan, Fuermetz Julian, Sack Ulrich, Bauer Katrin, Hohenadel Maximilian, Wiegel Martin, Kaisers Udo X, Heinke Wolfgang
Cluster of Excellence "Languages of Emotion," Freie Universität Berlin Berlin, Germany.
Front Psychol. 2011 Apr 5;2:58. doi: 10.3389/fpsyg.2011.00058. eCollection 2011.
This study explores effects of instrumental music on the hormonal system (as indicated by serum cortisol and adrenocorticotropic hormone), the immune system (as indicated by immunoglobulin A) and sedative drug requirements during surgery (elective total hip joint replacement under spinal anesthesia with light sedation). This is the first study investigating this issue with a double-blind design using instrumental music.
METHODOLOGY/PRINCIPAL FINDINGS: Patients (n = 40) were randomly assigned either to a music group (listening to instrumental music), or to a control group (listening to a non-musical placebo stimulus). Both groups listened to the auditory stimulus about 2 h before, and during the entire intra-operative period (during the intra-operative light sedation, subjects were able to respond lethargically to verbal commands). Results indicate that, during surgery, patients of the music group had a lower propofol consumption, and lower cortisol levels, compared to the control group.
CONCLUSION/SIGNIFICANCE: Our data show that listening to music during surgery under regional anesthesia has effects on cortisol levels (reflecting stress-reducing effects) and reduces sedative requirements to reach light sedation.
本研究探讨了器乐对激素系统（以血清皮质醇和促肾上腺皮质激素表示）、免疫系统（以免疫球蛋白A表示）以及手术期间（在脊髓麻醉加轻度镇静下进行择期全髋关节置换术）镇静药物需求的影响。这是第一项采用双盲设计使用器乐来研究该问题的研究。
方法/主要发现：患者（n = 40）被随机分为音乐组（听器乐）或对照组（听非音乐安慰剂刺激）。两组在术前约2小时以及整个手术期间（在术中轻度镇静期间，受试者能够对口头指令做出慵懒反应）都聆听听觉刺激。结果表明，与对照组相比，音乐组患者在手术期间丙泊酚消耗量更低，皮质醇水平也更低。
结论/意义：我们的数据表明，在区域麻醉下手术期间听音乐对皮质醇水平有影响（反映出减轻压力的作用），并降低了达到轻度镇静所需的镇静药物剂量。
