Rao Venkata, Kiran Ravi
Department of Biochemistry, Katuri Medical College, Katuri Chinakondrupadu, Guntur - 522 019, Andhra Pradesh, India.
J Cardiovasc Dis Res. 2011 Jan;2(1):57-60. doi: 10.4103/0975-3583.78598.
Coronary artery disease (CAD) is the most common cause of sudden death, none and death of men and women over 20 years of age. The aim of the study was to know if there is any linear correlation between oxidants and abnormal lipid profile parameters in CAD.
The present study includes 42 known CAD cases (age = 41-75 years) and 33 age- and sex-matched healthy controls. Malondialdehyde ( MDA), total cholesterol, high-density lipoprotein (HDL) cholesterol, and triacylglyceride were measured and low-density lipoprotein (LDL) cholesterol was calculated in both cases and controls, respectively.
MDA was significantly increased in cases than controls (P = 0.0000001). Total cholesterol was high in cases than controls (P = 0.0000001). HDL cholesterol was significantly decreased in cases than controls (P = 0.0000001). LDL cholesterol was high in cases than controls (P = 0.0000001). Triacylglyceride was high in cases than controls (P = 0.0000001). Insignificant positive correlation were observed between MDA and total cholesterol (r = 0.258), between MDA and LDL cholesterol (r = 0.199), and between MDA and HDL cholesterol (r = 0.134). Negative correlation was observed between MDA and triacylglyceride (r = -0.314).
Increased oxidative stress and abnormal lipid profile were observed in CAD cases. Our study showed that statistically significant linear relationship could not be established between increased oxidative stress and abnormal lipid profile parameters, suggesting that increased oxidative stress and abnormal lipid profile are two independent risk factors in the pathomechanism of atherogenesis.
冠状动脉疾病（CAD）是20岁以上男性和女性猝死、非致命性心肌梗死和死亡的最常见原因。本研究的目的是了解CAD患者中氧化剂与异常血脂谱参数之间是否存在线性相关性。
本研究纳入42例已知CAD患者（年龄41 - 75岁）和33例年龄及性别匹配的健康对照者。分别测定了病例组和对照组的丙二醛（MDA）、总胆固醇、高密度脂蛋白（HDL）胆固醇和甘油三酯，并计算了低密度脂蛋白（LDL）胆固醇。
病例组的MDA显著高于对照组（P = 0.0000001）。病例组的总胆固醇高于对照组（P = 0.0000001）。病例组的HDL胆固醇显著低于对照组（P = 0.0000001）。病例组的LDL胆固醇高于对照组（P = 0.0000001）。病例组的甘油三酯高于对照组（P = 0.0000001）。MDA与总胆固醇之间（r = 0.258）、MDA与LDL胆固醇之间（r = 0.199）以及MDA与HDL胆固醇之间（r = 0.134）观察到无显著正相关。MDA与甘油三酯之间观察到负相关（r = -0.314）。
CAD患者存在氧化应激增加和血脂谱异常。我们的研究表明，氧化应激增加与异常血脂谱参数之间无法建立统计学上显著的线性关系，提示氧化应激增加和血脂谱异常是动脉粥样硬化发病机制中的两个独立危险因素。
