植物提取物对阿尔茨海默病的影响：对治疗途径的洞察
Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues.
作者信息
Obulesu M, Rao Dowlathabad Muralidhara
机构信息
Capital College, Garden City Group of Institutions, Bangalore, India.
出版信息
J Neurosci Rural Pract. 2011 Jan;2(1):56-61. doi: 10.4103/0976-3147.80102.
Abstract
Alzheimer's disease (AD) is a devastative neurodegenerative disorder which needs adequate studies on effective treatment options. The extracts of plants and their effect on the amelioration of AD symptoms have been extensively studied. This paper summarizes the mechanisms like acetylcholinesterase (AChE) inhibition, modification of monoamines, antiamyloid aggregation effect, and antioxidant activity which are actively entailed in the process of amelioration of AD symptoms. These effects are induced by extracts of a few plants of different origin like Yizhi Jiannao, Moringa oleifera (Drumstick tree), Ginkgo Biloba (Ginkgo/Maidenhair tree), Cassia obtisufolia (Sicklepod), Desmodium gangeticum (Sal Leaved Desmodium), Melissa officinalis (Lemon Balm), and Salvia officinalis (Garden sage, common sage).
摘要
阿尔茨海默病（AD）是一种毁灭性的神经退行性疾病，需要对有效的治疗方案进行充分研究。植物提取物及其对AD症状改善的作用已得到广泛研究。本文总结了在AD症状改善过程中积极涉及的机制，如乙酰胆碱酯酶（AChE）抑制、单胺修饰、抗淀粉样蛋白聚集作用和抗氧化活性。这些作用是由一些不同来源的植物提取物诱导的，如益智健脑、辣木（鼓槌树）、银杏（银杏/白果树）、决明子（望江南）、金钱草（金钱草）、香蜂草（柠檬香脂）和鼠尾草（花园鼠尾草、普通鼠尾草）。
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