Brozmanová J
Laboratórium molekulárnej genetiky, Ustav experimentálnej onkológie SAV, Bratislava, Slovenská republika.
Klin Onkol. 2011;24(3):171-9.
Selenium (Se) is an essential dietary component for all animals, including human beings, that is regarded as a protective agent against cancer. Although the mode of its anticancer action is not yet fully understood, several mechanisms, such as antioxidant protection through selenoenzymes, stimulation of DNA repair, and apoptosis in tumor prestages have all been proposed. Despite the unsupported results of the last "SELECT" trial, the cancer-preventing activity of Se has been demonstrated in a majority of epidemiological studies. Moreover, recent studies suggest that Se has a potential to be used not only in cancer prevention but also in cancer treatment, where in combination with other anticancer drugs or radiation it may increase the efficacy of cancer therapy. In combating cancer cells, Se acts as a prooxidant rather than an antioxidant, inducing apoptosis through the generation of oxidative stress. Thus, inorganic Se compounds, having high redox potency, represent a promising option in cancer therapy.
硒（Se）是包括人类在内的所有动物必需的膳食成分，被视为抗癌保护剂。尽管其抗癌作用方式尚未完全明确，但已提出了多种机制，如通过硒酶进行抗氧化保护、刺激DNA修复以及在肿瘤前期诱导细胞凋亡。尽管上一次“SELECT”试验结果未得到支持，但在大多数流行病学研究中已证明硒具有防癌活性。此外，最近的研究表明，硒不仅有用于癌症预防的潜力，还可用于癌症治疗，与其他抗癌药物或放疗联合使用时，可能会提高癌症治疗的疗效。在对抗癌细胞时，硒作为促氧化剂而非抗氧化剂，通过产生氧化应激诱导细胞凋亡。因此，具有高氧化还原能力的无机硒化合物在癌症治疗中是一个有前景的选择。
