沙泊康唑（R66 905）与两性霉素B及伊曲康唑相比，对曲霉属真菌的体外活性。

In vitro activity of saperconazole (R66 905) compared with amphotericin B and itraconazole against Aspergillus species.

作者信息

Denning D W, Hanson L H, Stevens D A

机构信息

Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128.

出版信息

Eur J Clin Microbiol Infect Dis. 1990 Sep;9(9):693-7. doi: 10.1007/BF01964275.

DOI:10.1007/BF01964275

PMID:2171940

Abstract

Twenty isolates of aspergillus were tested against saperconazole and 16 of these against itraconazole and amphotericin B using a macrodilution broth method. For 18 (90%) of 20 isolates tested against saperconazole, MICs were less than or equal to 3.1 mg/l and for 15 (75%) of 20 isolates MFCs were less than or equal to 3.1 mg/l. For 9 (56%) of 16 isolates tested against itraconazole, MICs were less than or equal to 3.1 mg/l, and for 4 (33%) of 12 isolates MFCs were less than or equal to 3.1 mg/l. For all 16 isolates tested against amphotericin B MICs and MFCs were less than or equal to 4.0 mg/l; for 11 of 16 isolates MICs were less than or equal to 2.0 mg/l. Saperconazole appears to be highly active against Aspergillus spp. in vitro, with a bimodal distribution of MICs and MFCs.

摘要

采用大剂量稀释肉汤法，对20株曲霉菌分离株进行了沙泊康唑测试，其中16株同时进行了伊曲康唑和两性霉素B测试。在针对沙泊康唑测试的20株分离株中，18株（90%）的最低抑菌浓度（MIC）小于或等于3.1mg/l，20株分离株中有15株（75%）的最低杀菌浓度（MFC）小于或等于3.1mg/l。在针对伊曲康唑测试的16株分离株中，9株（56%）的MIC小于或等于3.1mg/l，12株分离株中有4株（33%）的MFC小于或等于3.1mg/l。在针对两性霉素B测试的所有16株分离株中，MIC和MFC均小于或等于4.0mg/l；16株分离株中有11株的MIC小于或等于2.0mg/l。沙泊康唑在体外对曲霉菌属似乎具有高活性，其MIC和MFC呈双峰分布。