J Biomed Opt. 2011 Jun;16(6):060502. doi: 10.1117/1.3584846.
A clinical trial comprising 334 pigmented and vascular lesions has been performed in three Riga clinics by means of multispectral imaging analysis. The imaging system Nuance 2.4 (CRi) and self-developed software for mapping of the main skin chromophores were used. Specific features were observed and analyzed for malignant skin melanomas: notably higher absorbance (especially as the difference of optical density relative to the healthy skin), uneven chromophore distribution over the lesion area, and the possibility to select the "melanoma areas" in the correlation graphs of chromophores. The obtained results indicate clinical potential of this technology for noncontact selection of melanoma from other pigmented and vascular skin lesions.
一项包含 334 例色素性和血管性病变的临床试验已在里加的三个诊所通过多光谱成像分析完成。该研究使用了 Nuance 2.4（CRi）成像系统和自行开发的用于主要皮肤色团映射的软件。对恶性皮肤黑色素瘤的观察和分析显示出了其特定的特征：尤其是更高的吸收率（尤其是相对于健康皮肤的光密度差异）、病变区域内色素分布不均匀，以及在相关的色团图谱中选择“黑色素瘤区域”的可能性。研究结果表明，该技术具有从其他色素性和血管性皮肤病变中选择黑色素瘤的临床潜力。
