Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
J Clin Densitom. 2011 Jul-Sep;14(3):313-20. doi: 10.1016/j.jocd.2011.05.006. Epub 2011 Jul 1.
Diabetic foot diseases, such as ulcerations, infections, and neuropathic (Charcot's) arthropathy, are major complications of diabetes mellitus (DM) and peripheral neuropathy (PN) and may cause osteolysis (bone loss) in foot bones. The purposes of our study were to make computed tomography (CT) measurements of foot-bone volumes and densities and to determine measurement precision (percent coefficients of variation for root-mean-square standard deviations) and least significant changes (LSCs) in these percentages that could be considered biologically real with 95% confidence. Volumetric quantitative CT scans were performed and repeated on 10 young healthy subjects and 13 subjects with DM and PN. Two raters used the original- and repeat-scan data sets to make measurements of volumes and bone mineral densities (BMDs) of the tarsal and metatarsal bones of the 2 feet (24 bones). Precisions for the bones ranged from 0.1% to 0.9% for volume measurements and from 0.6% to 1.9% for BMD measurements. The LSCs ranged from 0.4% to 2.5% for volume measurements and from 1.5% to 5.4% for BMD measurements. Volumetric quantitative CT provides precise measurements of volume and BMD for metatarsal and tarsal bones, where diabetic foot diseases commonly occur.
糖尿病足疾病，如溃疡、感染和神经病变性（夏科氏）关节病，是糖尿病（DM）和周围神经病变（PN）的主要并发症，可能导致足部骨骼溶骨（骨丢失）。我们的研究目的是对足部骨骼体积和密度进行计算机断层扫描（CT）测量，并确定这些百分比的测量精度（均方根标准偏差的根均方系数变化）和最小有意义变化（LSC），这些百分比在 95%置信区间内可被认为具有生物学意义。对 10 名年轻健康受试者和 13 名患有 DM 和 PN 的受试者进行了容积定量 CT 扫描和重复扫描。两名评估者使用原始和重复扫描数据集对 2 只脚（24 只骨骼）的跗骨和跖骨的体积和骨矿物质密度（BMD）进行测量。骨骼的精度范围为体积测量的 0.1%至 0.9%，BMD 测量的 0.6%至 1.9%。体积测量的 LSC 范围为 0.4%至 2.5%，BMD 测量的 LSC 范围为 1.5%至 5.4%。容积定量 CT 可对糖尿病足疾病常见发生的跖骨和跗骨的体积和 BMD 进行精确测量。
