Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Mol Cell. 2011 Jul 8;43(1):3-5. doi: 10.1016/j.molcel.2011.06.010.
Compelling evidence suggests that metabolic pathways are coordinated through reversible acetylation of metabolic enzymes in response to nutrient availability. In this issue of Molecular Cell, Jiang et al. (2011) show that the rate-limiting enzyme in gluconeogenesis, phosphoenolpyruvate carboxykinase 1, is regulated through reversible acetylation by SIRT2 and p300.
有强有力的证据表明，代谢途径是通过代谢酶的可逆乙酰化来协调的，以响应营养物质的可用性。在本期《分子细胞》中，Jiang 等人（2011）表明，糖异生的限速酶——磷酸烯醇丙酮酸羧激酶 1——通过 SIRT2 和 p300 的可逆乙酰化来调节。
