Peel S, Stewart I
Anat Embryol (Berl). 1979 Jan 30;155(2):209-19. doi: 10.1007/BF00305753.
The ultrastructural changes occurring in the metrial gland in the latter half of pregnancy in the rat have been studied. Typical palely stained granulated cells are present in the metrial gland up to day 20 but many granulated cells show variations in appearance which may be associated with degeneration. In some the cytoplasm is more darkly stained and such cells often have apparently empty areas of cytoplasm adjacent to the granules. From day 14 onwards many areas of the gland show cellular debris, apparently resulting from lysis of the granulated cells. However, occasionally normal granulated cells are present in blood vessels and have been observed apparently penetrating the vascular endothelium. A variety of changes was also noted in the stromal cell population. Inclusions became apparent in many of these cells; some of these consisted of lipid while others resembled granules from the typical granulated cells. Other cells with numerous inclusions appeared to be macrophages. Lysis of granulated cells in situ is compatible with suggestions that the metrial gland produces a holocrine secretion, though some normal granulated cells enter blood vessels. The stromal cells may have a phagocytic role in late pregnancy but evidence for this was inconclusive.
对大鼠妊娠后半期子宫蜕膜腺发生的超微结构变化进行了研究。直至第20天，子宫蜕膜腺中均存在典型的淡染颗粒细胞，但许多颗粒细胞出现外观变化，这可能与退变有关。在一些细胞中，细胞质染色更深，此类细胞的颗粒附近常常有明显的细胞质空泡区。从第14天起，腺的许多区域出现细胞碎片，显然是颗粒细胞溶解所致。然而，偶尔在血管中会出现正常的颗粒细胞，并且观察到它们显然穿透了血管内皮。在基质细胞群体中也注意到了多种变化。许多此类细胞中出现了内含物；其中一些由脂质组成，而另一些类似于典型颗粒细胞的颗粒。其他含有大量内含物的细胞似乎是巨噬细胞。颗粒细胞原位溶解与子宫蜕膜腺产生全浆分泌的观点相符，尽管一些正常颗粒细胞进入了血管。基质细胞在妊娠后期可能具有吞噬作用，但支持这一点的证据并不确凿。
