Psychobiology of Stress & Health Lab, Psychology Department, Mount Allison University, Sackville, New Brunswick, Canada.
J Womens Health (Larchmt). 2013 Apr;22(4):385-9. doi: 10.1089/jwh.2012.3785. Epub 2012 Oct 9.
We examined depressive symptoms, C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels during early to-midgestation.
We measured depressive symptoms on the Patient Health Questionnaire-9 (PHQ-9), and serum CRP, IL-6, and TNF-α levels twice in 27 pregnant women.
After adjustment, depressive symptoms prospectively (β=0.42, p<0.05 at 16-20 weeks of gestation) and concurrently (β=0.54, p<0.01 at 7-10 weeks of gestation) predicted elevated CRP [F (2, 14)=9.20, p=0.003, R(2)=0.57 and F (3, 15)=9.08, p=0.001, R(2)=0.64, respectively]. There were similar patterns of results for TNF-α (β=0.72, p<0.01) and IL-6 levels (β=0.39, p<0.05) at 7-10 weeks of gestation [F (2,19)=8.84, p=0.002, R(2)=0.48]. Furthermore, the association between depressive symptoms at 7-10 weeks of gestation and increased IL-6 levels at 16-20 weeks of gestation approached statistical significance. We confirmed the findings with the Wilcoxon signed rank test (IL-6: Z=2.44, p=0.015; TNF-α: Z=1.94, p=0.05; CRP: approached statistical significance).
These pilot data suggest that depressive symptoms may be associated with inflammatory markers during early to-midgestation.
我们研究了妊娠中期早期至中期的抑郁症状、C 反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平。
我们使用患者健康问卷-9（PHQ-9）测量了 27 名孕妇的抑郁症状，并两次测量了血清 CRP、IL-6 和 TNF-α 水平。
调整后，抑郁症状前瞻性（β=0.42，妊娠 16-20 周时 p<0.05）和同时性（β=0.54，妊娠 7-10 周时 p<0.01）预测 CRP 升高[F（2，14）=9.20，p=0.003，R²=0.57 和 F（3，15）=9.08，p=0.001，R²=0.64]。TNF-α（β=0.72，p<0.01）和 IL-6 水平（β=0.39，p<0.05）在妊娠 7-10 周时也存在类似的结果[F（2，19）=8.84，p=0.002，R²=0.48]。此外，妊娠 7-10 周时的抑郁症状与妊娠 16-20 周时的 IL-6 水平升高之间存在统计学意义上的关联。我们通过 Wilcoxon 符号秩检验证实了这些发现（IL-6：Z=2.44，p=0.015；TNF-α：Z=1.94，p=0.05；CRP：接近统计学意义）。
这些初步数据表明，抑郁症状可能与妊娠中期早期至中期的炎症标志物有关。
