Hsu D H, de Waal Malefyt R, Fiorentino D F, Dang M N, Vieira P, de Vries J, Spits H, Mosmann T R, Moore K W
Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.
Science. 1990 Nov 9;250(4982):830-2. doi: 10.1126/science.2173142.
Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.
细胞因子合成抑制因子（CSIF；白细胞介素-10）是小鼠TH2 T细胞克隆的产物，可抑制小鼠TH1 T细胞克隆的细胞因子合成，它与爱泼斯坦-巴尔病毒BCRF1中一个未鉴定的开放阅读框具有广泛的序列相似性。重组BCRF1蛋白模拟白细胞介素-10的活性，表明BCRF1可能在病毒与宿主免疫系统的相互作用中发挥作用。
