Noguez M Olivia, Marcelino Vanessa, Rodríguez Hortensia, Martín Osnieski, Martínez Joel O, Arroyo Gabriel A, Pérez Francisco J, Suárez Margarita, Miranda René
Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán-UNAM, Estado de México, 54754, Mexico; E-Mails:
Int J Mol Sci. 2011;12(4):2641-9. doi: 10.3390/ijms12042641. Epub 2011 Apr 18.
A green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrum's acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50-75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed.
已经设计出一种绿色方法，用于使用丙二酸亚异丙酯合成一组十个4-芳基取代的-5-烷氧基羰基-6-甲基-3,4-二氢-2(1H)-吡啶酮，主要反应条件是无溶剂以及除多组分方案外还采用红外辐射活化。转化反应以适度的产率（50-75%）和合理的反应速率（3小时）进行。值得注意的是，还获得了新型双-3,4-二氢吡啶酮类的两个新分子。此外，还进行了不使用红外辐射的比较。
