Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy.
Rev Med Virol. 2011 Nov;21(6):347-57. doi: 10.1002/rmv.702. Epub 2011 Jul 5.
In viral infections, a memory T-cell population comprises multiple subtypes of cells, distributed in diverse anatomic compartments and possibly re-circulating among them. Accordingly, memory T cells display distinct phenotypes and functions, depending on the nature of the infecting virus, the anatomic location of the infection, and the differences between the sites of active infection and T-cell collection. This paper explores the body compartments where virus-specific CD8(+) T cells have been found during chronic hepatitis C virus infection, describes the cells' memory qualities, and discusses how they are spatially regulated, in comparison with other human viral infections. Understanding the role of compartmentalization and diversity of HCV-specific memory T-cell subsets may be the key to developing effective immunotherapies.
在病毒感染中，记忆 T 细胞群体包含多种细胞亚型，分布在不同的解剖部位，并可能在它们之间重新循环。因此，记忆 T 细胞根据感染病毒的性质、感染的解剖部位以及活跃感染部位和 T 细胞采集部位之间的差异，表现出不同的表型和功能。本文探讨了在慢性丙型肝炎病毒感染期间在哪些身体部位发现了病毒特异性 CD8(+) T 细胞，描述了这些细胞的记忆特性，并讨论了它们如何与其他人类病毒感染相比在空间上受到调节。了解丙型肝炎病毒特异性记忆 T 细胞亚群的分隔和多样性的作用可能是开发有效免疫疗法的关键。
