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土生土长的环球肠侵袭性大肠杆菌血清型 O:3/4——一组成功的新兴人畜共患病病原体。

Yersinia enterocolitica palearctica serobiotype O:3/4--a successful group of emerging zoonotic pathogens.

机构信息

Max von Pettenkofer-Institute, LMU, Munich, Germany.

出版信息

BMC Genomics. 2011 Jul 6;12:348. doi: 10.1186/1471-2164-12-348.

DOI:10.1186/1471-2164-12-348
PMID:21733159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3161016/
Abstract

BACKGROUND

High-pathogenic Y. enterocolitica ssp. enterocolitica caused several human outbreaks in Northern America. In contrast, low pathogenic Y. enterocolitica ssp. palearctica serobiotype O:3/4 is responsible for sporadic cases worldwide with asymptomatic pigs being the main source of infection. Genomes of three Y. enterocolitica ssp. palearctica serobiotype O:3/4 human isolates (including the completely sequenced Y11 German DSMZ type strain) were compared to the high-pathogenic Y. enterocolitica ssp. enterocolitica 8081 O:8/1B to address the peculiarities of the O:3/4 group.

RESULTS

Most high-pathogenicity-associated determinants of Y. enterocolitica ssp. enterocolitica (like the High-Pathogenicity Island, yts1 type 2 and ysa type 3 secretion systems) are absent in Y. enterocolitica ssp. palearctica serobiotype O:3/4 genomes. On the other hand they possess alternative putative virulence and fitness factors, such as a different ysp type 3 secretion system, an RtxA-like and insecticidal toxins, and a N-acetyl-galactosamine (GalNAc) PTS system (aga-operon). Horizontal acquisition of two prophages and a tRNA-Asn-associated GIYep-01 genomic island might also influence the Y. enterocolitica ssp. palearctica serobiotype O:3/4 pathoadaptation. We demonstrated recombination activity of the PhiYep-3 prophage and the GIYep-01 island and the ability of the aga-operon to support the growth of the Y. enterocolitica ssp. enterocolitica O:8/1B on GalNAc.

CONCLUSIONS

Y. enterocolitica ssp. palearctica serobiotype O:3/4 experienced a shift to an alternative patchwork of virulence and fitness determinants that might play a significant role in its host pathoadaptation and successful worldwide dissemination.

摘要

背景

高致病性 Y. enterocolitica ssp. enterocolitica 在美国北部引发了几个人类疫情。相比之下，低致病性 Y. enterocolitica ssp. palearctica 血清型 O:3/4 是导致全世界散发病例的原因，无症状猪是主要感染源。将三个 Y. enterocolitica ssp. palearctica 血清型 O:3/4 人类分离株的基因组（包括完全测序的 Y11 德国 DSMZ 标准株）与高致病性 Y. enterocolitica ssp. enterocolitica 8081 O:8/1B 进行比较，以解决 O:3/4 组的特殊性。

结果

Y. enterocolitica ssp. enterocolitica 的大多数高致病性相关决定因素（如高致病性岛、yts1 型 2 和 ysa 型 3 分泌系统）在 Y. enterocolitica ssp. palearctica 血清型 O:3/4 基因组中缺失。另一方面，它们拥有替代的潜在毒力和适应性因素，如不同的 ysp 型 3 分泌系统、RtxA 样和杀虫毒素以及 N-乙酰半乳糖胺（GalNAc）PTS 系统（aga 操纵子）。两个噬菌体和一个 tRNA-Asn 相关的 GIYep-01 基因组岛的水平获得也可能影响 Y. enterocolitica ssp. palearctica 血清型 O:3/4 的病原适应。我们证明了 PhiYep-3 噬菌体和 GIYep-01 岛的重组活性以及 aga 操纵子在 GalNAc 上支持 Y. enterocolitica ssp. enterocolitica O:8/1B 生长的能力。

结论

Y. enterocolitica ssp. palearctica 血清型 O:3/4 经历了一种替代的毒力和适应性决定因素的转变，这可能在其宿主病原适应和在全球范围内成功传播中发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/a240afcd4f29/1471-2164-12-348-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/7e04b74a6afe/1471-2164-12-348-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/f36deffa1c9d/1471-2164-12-348-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/8e9d9073e37c/1471-2164-12-348-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/bf231c04a7b1/1471-2164-12-348-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/ba264fe2c20d/1471-2164-12-348-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/a240afcd4f29/1471-2164-12-348-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/7e04b74a6afe/1471-2164-12-348-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/f36deffa1c9d/1471-2164-12-348-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/8e9d9073e37c/1471-2164-12-348-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/bf231c04a7b1/1471-2164-12-348-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/ba264fe2c20d/1471-2164-12-348-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a44c/3161016/a240afcd4f29/1471-2164-12-348-6.jpg

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