Department of Pathology, Singapore General Hospital, Singapore.
Epidemiol Infect. 2012 Mar;140(3):535-8. doi: 10.1017/S0950268811001129. Epub 2011 Jun 21.
This study was performed to determine the prevalence, distribution of specimen sources, and antimicrobial susceptibility of the Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) species complex in Singapore. One hundred and ninety-three non-replicate Acb species complex clinical isolates were collected from six hospitals over a 1-month period in 2006. Of these, 152 (78·7%) were identified as A. baumannii, 18 (9·3%) as 'Acinetobacter pittii' [genomic species (gen. sp.) 3], and 23 (11·9%) as 'Acinetobacter nosocomialis' (gen. sp. 13TU). Carbapenem resistance was highest in A. baumannii (72·4%), followed by A. pittii (38·9%), and A. nosocomialis (34·8%). Most carbapenem-resistant A. baumannii and A. nosocomialis possessed the bla(OXA-23-like) gene whereas carbapenem-resistant A. pittii possessed the bla(OXA-58-like) gene. Two imipenem-resistant strains (A. baumannii and A. pittii) had the bla(IMP-like) gene. Representatives of carbapenem-resistant A. baumannii were related to European clones I and II.
本研究旨在确定新加坡产酸克雷伯菌-鲍曼不动杆菌（Acb）种复合体的流行率、标本来源分布和抗菌药物敏感性。2006 年，在一个月的时间内，从六家医院采集了 193 株非重复 Acb 种复合体临床分离株。其中，152 株（78.7%）鉴定为鲍曼不动杆菌，18 株（9.3%）为“醋酸钙不动杆菌”[基因组种（gen. sp.）3]，23 株（11.9%）为“医院不动杆菌”（gen. sp. 13TU）。碳青霉烯类耐药性在鲍曼不动杆菌中最高（72.4%），其次是醋酸钙不动杆菌（38.9%）和医院不动杆菌（34.8%）。大多数碳青霉烯类耐药的鲍曼不动杆菌和医院不动杆菌携带 bla(OXA-23 样）基因，而碳青霉烯类耐药的醋酸钙不动杆菌携带 bla(OXA-58 样）基因。两株耐亚胺培南的菌株（鲍曼不动杆菌和醋酸钙不动杆菌）携带 bla(IMP 样）基因。耐碳青霉烯类的鲍曼不动杆菌代表株与欧洲克隆 I 和 II 有关。
