School of Mathematics and Statistics, University of Sydney, Sydney, Australia.
Genet Mol Biol. 2011 Apr;34(2):177-86. doi: 10.1590/s1415-47572011000200002. Epub 2011 Apr 1.
In 1939 N.I. Ermolaeva published the results of an experiment which repeated parts of Mendel's classical experiments. On the basis of her experiment she concluded that Mendel's principle that self-pollination of hybrid plants gave rise to segregation proportions 3:1 was false. The great probability theorist A.N. Kolmogorov reviewed Ermolaeva's data using a test, now referred to as Kolmogorov's, or Kolmogorov-Smirnov, test, which he had proposed in 1933. He found, contrary to Ermolaeva, that her results clearly confirmed Mendel's principle. This paper shows that there were methodological flaws in Kolmogorov's statistical analysis and presents a substantially adjusted approach, which confirms his conclusions. Some historical commentary on the Lysenko-era background is given, to illuminate the relationship of the disciplines of genetics and statistics in the struggle against the prevailing politically-correct pseudoscience in the Soviet Union. There is a Brazilian connection through the person of Th. Dobzhansky.
1939 年,N.I. Ermolaeva 公布了重复孟德尔经典实验部分内容的实验结果。基于她的实验,她得出结论,孟德尔的自交杂种植物产生分离比例 3:1 的原理是错误的。伟大的概率论学家 A.N. Kolmogorov 使用一种现在称为 Kolmogorov 或 Kolmogorov-Smirnov 检验的方法来检验 Ermolaeva 的数据,他在 1933 年提出了这种方法。他发现,与 Ermolaeva 的结论相反,她的结果清楚地证实了孟德尔的原理。本文表明,Kolmogorov 的统计分析存在方法上的缺陷,并提出了一种实质性的调整方法,该方法证实了他的结论。本文还对李森科时代的背景进行了一些历史评论,以阐明遗传学和统计学在与苏联流行的政治正确伪科学作斗争中的关系。通过 Th. Dobzhansky 这个人,还与巴西有联系。