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伯氏疟原虫端粒内的长插入导致染色体大小多态性。

Long insertions within telomeres contribute to chromosome size polymorphism in Plasmodium berghei.

作者信息

Pace T, Ponzi M, Dore E, Janse C, Mons B, Frontali C

机构信息

Laboratory of Cellular Biology, Istituto Superiore di Sanità, Rome, Italy.

出版信息

Mol Cell Biol. 1990 Dec;10(12):6759-64. doi: 10.1128/mcb.10.12.6759-6764.1990.

DOI:10.1128/mcb.10.12.6759-6764.1990
PMID:2174115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362954/
Abstract

During prolonged in vivo mitotic multiplication of a Plasmodium berghei ANKA clone (8417HP), parasites that contained an enlarged version of chromosome 4 were observed. Restriction mapping and hybridization results demonstrated that the extra DNA present in the enlarged chromosome consists of 2.3-kb tandem repeats, known to be normally located in subtelomeric position at several chromosomal ends but absent in the original chromosome. The inserted 2.3-kb units appeared to interrupt one of the original telomeres and to create an internal (approximately 1-kb-long) telomeric sequence.

摘要

在伯氏疟原虫ANKA克隆（8417HP）的长期体内有丝分裂增殖过程中，观察到含有4号染色体放大版本的寄生虫。限制性图谱分析和杂交结果表明，放大染色体中存在的额外DNA由2.3 kb的串联重复序列组成，已知该序列通常位于几个染色体末端的亚端粒位置，但在原始染色体中不存在。插入的2.3 kb单位似乎中断了一个原始端粒，并产生了一个内部（约1 kb长）端粒序列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c555/362954/dfda1d10bfb9/molcellb00048-0672-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c555/362954/0e13750add1a/molcellb00048-0671-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c555/362954/dfda1d10bfb9/molcellb00048-0672-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c555/362954/0e13750add1a/molcellb00048-0671-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c555/362954/dfda1d10bfb9/molcellb00048-0672-a.jpg

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本文引用的文献

1
Unusual DNA sequences associated with the ends of yeast chromosomes.与酵母染色体末端相关的异常DNA序列。
Nature. 1984;310(5973):157-60. doi: 10.1038/310157a0.
2
Organization of DNA sequences and replication origins at yeast telomeres.酵母端粒处DNA序列的组织及复制起点
Cell. 1983 Jun;33(2):563-73. doi: 10.1016/0092-8674(83)90437-3.
3
Transfer of yeast telomeres to linear plasmids by recombination.通过重组将酵母端粒转移至线性质粒。
恶性疟原虫中与间日疟原虫和约氏疟原虫黏附蛋白基因同源的基因，该基因可转录但不翻译。
Infect Immun. 2001 Jun;69(6):3635-45. doi: 10.1128/IAI.69.6.3635-3645.2001.
4
Telomere variation in Xenopus laevis.非洲爪蟾的端粒变异
Mol Cell Biol. 1998 Jan;18(1):269-75. doi: 10.1128/MCB.18.1.269.
5
Characterization of recombination in the HLA class II region.HLA II类区域重组的特征分析。
Am J Hum Genet. 1997 Feb;60(2):397-407.
6
DNA organization and polymorphism of a wild-type Drosophila telomere region.野生型果蝇端粒区域的DNA组织与多态性
Chromosoma. 1995 Dec;104(4):229-41. doi: 10.1007/BF00352254.
7
Genome plasticity in Plasmodium.疟原虫的基因组可塑性
Genetica. 1994;94(2-3):91-100. doi: 10.1007/BF01443424.
8
Chromosome structure: DNA nucleotide sequence elements of a subset of the minichromosomes of the protozoan Trypanosoma brucei.染色体结构：原生动物布氏锥虫微小染色体亚组的DNA核苷酸序列元件
Mol Cell Biol. 1991 Aug;11(8):3823-34. doi: 10.1128/mcb.11.8.3823-3834.1991.
9
New nucleotide sequence data on the EMBL File Server.欧洲分子生物学实验室文件服务器上的新核苷酸序列数据。
Nucleic Acids Res. 1991 Jun 25;19(12):3467-82. doi: 10.1093/nar/19.12.3467.
10
Chromosome translocation in Plasmodium berghei.伯氏疟原虫中的染色体易位
Nucleic Acids Res. 1992 Feb 11;20(3):581-6. doi: 10.1093/nar/20.3.581.
Cell. 1984 Nov;39(1):191-201. doi: 10.1016/0092-8674(84)90205-8.
4
Chromosome-sized DNA molecules of Plasmodium falciparum.恶性疟原虫的染色体大小的DNA分子。
Science. 1985 Aug 16;229(4714):658-61. doi: 10.1126/science.3895435.
5
Chromosome size polymorphisms in Plasmodium falciparum can involve deletions and are frequent in natural parasite populations.恶性疟原虫的染色体大小多态性可能涉及缺失，并且在自然寄生虫种群中很常见。
Cell. 1986 Jan 17;44(1):87-95. doi: 10.1016/0092-8674(86)90487-3.
6
Genetic analysis of the human malaria parasite Plasmodium falciparum.人类疟原虫恶性疟原虫的基因分析。
Science. 1987 Jun 26;236(4809):1661-6. doi: 10.1126/science.3299700.
7
Homologous recombination within subtelomeric repeat sequences generates chromosome size polymorphisms in P. falciparum.端粒重复序列内的同源重组在恶性疟原虫中产生染色体大小多态性。
Cell. 1988 Jun 3;53(5):807-13. doi: 10.1016/0092-8674(88)90097-9.
8
Sequence and structure of a Plasmodium falciparum telomere.恶性疟原虫端粒的序列与结构
Mol Biochem Parasitol. 1988 Mar;28(2):85-94. doi: 10.1016/0166-6851(88)90055-2.
9
Long-range restriction maps of Plasmodium falciparum chromosomes: crossingover and size variation among geographically distant isolates.恶性疟原虫染色体的长程限制图谱：地理上遥远分离株之间的交叉与大小变异
Genomics. 1988 Nov;3(4):287-95. doi: 10.1016/0888-7543(88)90117-6.
10
Plasmodium vivax: karyotype polymorphism of field isolates.
Exp Parasitol. 1988 Dec;67(2):301-6. doi: 10.1016/0014-4894(88)90077-x.