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维甲酸可促进血小板衍生生长因子α受体基因的转录。

Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene.

作者信息

Wang C, Kelly J, Bowen-Pope D F, Stiles C D

机构信息

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.

出版信息

Mol Cell Biol. 1990 Dec;10(12):6781-4. doi: 10.1128/mcb.10.12.6781-6784.1990.

DOI:10.1128/mcb.10.12.6781-6784.1990
PMID:2174116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362958/
Abstract

Retinoic acid together with dibutyryl cyclic AMP stimulated transcription of the platelet-derived growth factor alpha-receptor gene in embryonal carcinoma cells (line F9). Processed mRNA transcripts appeared within 4 h after exposure to these agents, and functional alpha:alpha homodimers appeared within 24 h.

摘要

视黄酸与二丁酰环磷酸腺苷一起刺激胚胎癌细胞（F9细胞系）中血小板衍生生长因子α受体基因的转录。在接触这些试剂后4小时内出现加工后的mRNA转录本，24小时内出现功能性α:α同二聚体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857d/362958/6e6c6513acd0/molcellb00048-0695-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857d/362958/41119a08602f/molcellb00048-0694-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857d/362958/2bb5c110149f/molcellb00048-0694-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857d/362958/421b103f6219/molcellb00048-0694-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857d/362958/6e6c6513acd0/molcellb00048-0695-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857d/362958/41119a08602f/molcellb00048-0694-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857d/362958/2bb5c110149f/molcellb00048-0694-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857d/362958/421b103f6219/molcellb00048-0694-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857d/362958/6e6c6513acd0/molcellb00048-0695-a.jpg

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1
Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene.维甲酸可促进血小板衍生生长因子α受体基因的转录。
Mol Cell Biol. 1990 Dec;10(12):6781-4. doi: 10.1128/mcb.10.12.6781-6784.1990.
2
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3
Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells.
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4
Thrombomodulin gene regulation by cAMP and retinoic acid in F9 embryonal carcinoma cells.F9胚胎癌细胞中cAMP和视黄酸对血栓调节蛋白基因的调控。
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Induction of platelet-derived growth factor alpha- and beta-receptor mRNA and protein by platelet-derived growth factor BB.血小板源性生长因子BB对血小板源性生长因子α受体和β受体mRNA及蛋白的诱导作用
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Cyclic AMP analogs and retinoic acid influence the expression of retinoic acid receptor alpha, beta, and gamma mRNAs in F9 teratocarcinoma cells.环磷酸腺苷类似物和视黄酸影响F9畸胎瘤细胞中视黄酸受体α、β和γ信使核糖核酸的表达。
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Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.人α或β血小板衍生生长因子受体cDNA在幼稚造血细胞中的独立表达导致与促有丝分裂和趋化信号通路的功能偶联。
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Selective expression of PDGF A and its receptor during early mouse embryogenesis.血小板源性生长因子A及其受体在小鼠胚胎发育早期的选择性表达。
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Retinoic acid inducibility of the human PDGF-a gene is mediated by 5'-distal DNA motifs that overlap with basal enhancer and vitamin D response elements.

本文引用的文献

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Isolation of cDNA clones specific for collagen IV and laminin from mouse teratocarcinoma cells.从小鼠畸胎瘤细胞中分离出Ⅳ型胶原和层粘连蛋白特异性的cDNA克隆。
Proc Natl Acad Sci U S A. 1983 Oct;80(19):5880-4. doi: 10.1073/pnas.80.19.5880.
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Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.血小板衍生生长因子在结构上与猿猴肉瘤病毒假定的转化蛋白p28sis相关。
Nature. 1983;304(5921):35-9. doi: 10.1038/304035a0.
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Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.
人血小板衍生生长因子A基因的视黄酸诱导性由与基础增强子和维生素D反应元件重叠的5'-远端DNA基序介导。
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Expression of platelet-derived growth factor (PDGF) receptor alpha-subunit in mouse brain: comparison of Patch mutants and normal littermates.血小板衍生生长因子（PDGF）受体α亚基在小鼠脑中的表达：Patch突变体与正常同窝小鼠的比较。
Cell Mol Neurobiol. 1996 Aug;16(4):479-87. doi: 10.1007/BF02150228.
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Cell-type-specific expression of the platelet-derived growth factor alpha receptor: a role for GATA-binding protein.血小板衍生生长因子α受体的细胞类型特异性表达：GATA结合蛋白的作用。
Mol Cell Biol. 1996 Feb;16(2):712-23. doi: 10.1128/MCB.16.2.712.
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Structural analysis of chromosomal rearrangements associated with the developmental mutations Ph, W19H, and Rw on mouse chromosome 5.与小鼠5号染色体上发育突变Ph、W19H和Rw相关的染色体重排的结构分析。
Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7237-41. doi: 10.1073/pnas.91.15.7237.
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Platelet-derived growth factor alpha receptor gene expression: isolation and characterization of the promoter and upstream regulatory elements.血小板衍生生长因子α受体基因表达：启动子及上游调控元件的分离与鉴定
Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7061-5. doi: 10.1073/pnas.91.15.7061.
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Inhibition of nitric oxide synthesis in vascular smooth muscle by retinoids.类维生素A对血管平滑肌中一氧化氮合成的抑制作用。
Br J Pharmacol. 1994 Dec;113(4):1448-54. doi: 10.1111/j.1476-5381.1994.tb17159.x.
9
Thrombomodulin gene regulation by cAMP and retinoic acid in F9 embryonal carcinoma cells.F9胚胎癌细胞中cAMP和视黄酸对血栓调节蛋白基因的调控。
Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2155-9. doi: 10.1073/pnas.89.6.2155.
猿猴肉瘤病毒癌基因v-sis源自编码血小板衍生生长因子的基因。
Science. 1983 Jul 15;221(4607):275-7. doi: 10.1126/science.6304883.
4
Hormonal induction of differentiation in teratocarcinoma stem cells: generation of parietal endoderm by retinoic acid and dibutyryl cAMP.激素诱导畸胎癌干细胞分化：视黄酸和二丁酰环磷腺苷生成壁内胚层。
Cell. 1980 Sep;21(2):347-55. doi: 10.1016/0092-8674(80)90471-7.
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Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.对3T3细胞的刺激会诱导原癌基因c-fos的转录。
Nature. 1984;311(5985):433-8. doi: 10.1038/311433a0.
6
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines.人血小板衍生生长因子A链的cDNA序列、染色体定位及其在肿瘤细胞系中的表达
Nature. 1986;320(6064):695-9. doi: 10.1038/320695a0.
7
The reversal of an Adriamycin induced healing impairment with chemoattractants and growth factors.化疗吸引剂和生长因子对阿霉素诱导的愈合障碍的逆转作用。
Ann Surg. 1986 Feb;203(2):142-7. doi: 10.1097/00000658-198602000-00006.
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An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation.维甲酸的早期效应：一种mRNA（Era-1）的克隆，该mRNA在畸胎瘤干细胞分化过程中呈现快速且不依赖蛋白质合成的诱导现象。
Proc Natl Acad Sci U S A. 1988 Jan;85(2):329-33. doi: 10.1073/pnas.85.2.329.
9
Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos.血小板衍生生长因子A链在非洲爪蟾胚胎中由母体编码。
Science. 1988 Sep 2;241(4870):1223-5. doi: 10.1126/science.3413486.
10
The effects of different growth factors in subcutaneous wound chambers.不同生长因子在皮下伤口腔室中的作用。
Prog Clin Biol Res. 1988;266:77-91.