Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, CV4 7AL Coventry, UK.
Trends Cardiovasc Med. 2010 Jul;20(5):143-8. doi: 10.1016/j.tcm.2010.12.002.
Obesity has reached pandemic proportions and is associated with serious cardiometabolic sequelae including insulin resistance, diabetes, dyslipidemia, hypertension, and cardiovascular disease, where adipose tissue-secreted cytokines, that is, adipokines, have been implicated in these processes. Omentin is a novel adipokine preferentially produced by visceral adipose tissue with insulin-sensitizing effects, where circulating levels are decreased in insulin-resistant states, for example, obesity and diabetes. With respect to vascular biology, omentin causes vasodilatation of blood vessels and attenuates C-reactive protein-induced angiogenesis potentially via the nuclear factor B signaling pathway, a potent proinflammatory signaling pathway. Thus, omentin may have beneficial effects on the metabolic syndrome and could potentially be used as a biologic marker and/or pharmacologic agent in this respect.
肥胖已达到流行程度，并与严重的心脏代谢后果相关，包括胰岛素抵抗、糖尿病、血脂异常、高血压和心血管疾病，脂肪组织分泌的细胞因子，即脂肪因子，被认为与这些过程有关。网膜素是一种新型脂肪因子，主要由内脏脂肪组织产生，具有胰岛素增敏作用，在胰岛素抵抗状态下，如肥胖和糖尿病，循环水平降低。就血管生物学而言，网膜素可引起血管扩张，并通过核因子 B 信号通路减弱 C 反应蛋白诱导的血管生成，核因子 B 信号通路是一种有效的促炎信号通路。因此，网膜素可能对代谢综合征有益，并可能在这方面用作生物学标志物和/或药物。
