Demirci Oguz, Calhoun Vince D
The Mind Research Network, Albuquerque.
Eur Neurol Rev. 2009 Dec;4(2):103-106. doi: 10.17925/enr.2009.04.02.103.
Functional magnetic resonance imaging (fMRI) is an invaluable non-invasive instrument that has been used to investigate physiological disturbances that lead to manifest psychiatric illnesses. It is hoped that efficient application of fMRI can be utilised to characterise and diagnose mental illnesses such as schizophrenia. Although there are various fMRI research studies presenting very promising diagnosis results for schizophrenia, we believe that there is much to be done to develop effective diagnostic tools for clinical purposes. We present specific examples based mostly on our past and recent work together with various examples from the recent literature. We discuss where we currently stand in the efforts of fMRI being used for diagnosis of schizophrenia, examine common possible biases and offer some solutions with the hope that fMRI can be more efficiently used in diagnostic research.
功能磁共振成像（fMRI）是一种非常宝贵的非侵入性工具，已被用于研究导致明显精神疾病的生理紊乱。人们希望能够有效地应用fMRI来表征和诊断精神疾病，如精神分裂症。尽管有各种fMRI研究为精神分裂症呈现出非常有前景的诊断结果，但我们认为，要开发用于临床目的的有效诊断工具，仍有许多工作要做。我们主要基于我们过去和最近的工作给出具体例子，并结合近期文献中的各种例子。我们讨论了目前在将fMRI用于精神分裂症诊断的努力中所处的位置，研究常见的可能偏差，并提供一些解决方案，希望fMRI能够在诊断研究中得到更有效的应用。
