Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
Arch Virol. 2011 Oct;156(10):1823-9. doi: 10.1007/s00705-011-1061-5. Epub 2011 Jul 10.
Phylogenetic analysis of complete genomes of the avian coronaviruses avian infectious bronchitis (AIBV) and turkey coronavirus (TCoV) supported the hypothesis that numerous recombination events have occurred between these viruses. Although the two groups of viruses differed markedly in the sequence of the spike protein, the gene (S) encoding this protein showed no evidence of positive selection or of an elevated mutation rate. Rather, the data suggested that recombination events have homogenized the portions of the genome other than the S gene between the two groups of viruses, while continuing to maintain the two distinct, anciently diverged versions of the S gene. The latter hypothesis was supported by a phylogeny of S proteins from representative coronaviruses, in which S proteins of AIBV and TCoV fell in the same clade.
对禽传染性支气管炎病毒（AIBV）和火鸡冠状病毒（TCoV）这两种完整基因组的冠状病毒进行系统发育分析，支持了这两种病毒之间发生了大量重组事件的假说。虽然这两组病毒在刺突蛋白的序列上有明显差异，但编码该蛋白的基因（S）没有表现出正选择或突变率升高的证据。相反，数据表明，重组事件使两组病毒之间的基因组非 S 基因部分趋同，同时继续维持 S 基因的两个截然不同的古老分支版本。这一假说得到了来自代表性冠状病毒的 S 蛋白系统发育的支持，其中 AIBV 和 TCoV 的 S 蛋白属于同一进化枝。
