Pharmacological Research Department, Pharmaceuticals Development Research Laboratories, Teijin Institute for Bio-Medical Research, Hino, Tokyo 191-8512, Japan.
Steroids. 2011 Nov;76(12):1305-9. doi: 10.1016/j.steroids.2011.06.009. Epub 2011 Jul 2.
The chemokine interleukin-8 (IL-8) is involved in the pathogenesis of acute lung injury (ALI). Although several studies have reported that 1α,25-dihydroxyvitamin D(3) (1α,25(OH)(2)D(3)) suppresses IL-8 production in vitro and in vivo, 1α,25(OH)(2)D(3) has not been demonstrated to be effective in an animal model of ALI. Here, we determined its effects of 1α,25(OH)(2)D(3) in a hamster model where ALI was induced by lipopolysaccharide (LPS) inhalation. 1α,25(OH)(2)D(3) inhibited neutrophil recruitment in the lung by approximately 40% without increasing plasma calcium concentration, while it did not inhibit monocyte recruitment. Our findings show that vitamin D(3) analogues may be suitable as novel anti-inflammatory agents for ALI.
趋化因子白细胞介素-8（IL-8）参与急性肺损伤（ALI）的发病机制。尽管有几项研究报道 1α,25-二羟维生素 D（3）（1α,25（OH）（2）D（3））可抑制体外和体内的 IL-8 产生，但 1α,25（OH）（2）D（3）在 ALI 的动物模型中并未显示出有效性。在这里，我们在 LPS 吸入诱导的仓鼠 ALI 模型中确定了 1α,25（OH）（2）D（3）的作用。1α,25（OH）（2）D（3）抑制了约 40%的肺中性粒细胞募集，而不增加血浆钙浓度，同时它不抑制单核细胞募集。我们的研究结果表明，维生素 D3 类似物可能适合作为新型抗炎剂用于 ALI。
