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Anti-galactose-α-1,3-galactose IgE from allergic patients does not bind α-galactosylated glycans on intact therapeutic antibody Fc domains.

作者信息

Lammerts van Bueren Jeroen J, Rispens Theo, Verploegen Sandra, van der Palen-Merkus Tjitske, Stapel Steven, Workman Lisa J, James Hayley, van Berkel Patrick H C, van de Winkel Jan G J, Platts-Mills Thomas A E, Parren Paul W H I

出版信息

Nat Biotechnol. 2011 Jul 11;29(7):574-6. doi: 10.1038/nbt.1912.

DOI:10.1038/nbt.1912
PMID:21747378
Abstract
摘要

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Anti-galactose-α-1,3-galactose IgE from allergic patients does not bind α-galactosylated glycans on intact therapeutic antibody Fc domains.来自过敏患者的抗半乳糖-α-1,3-半乳糖 IgE 不与完整治疗性抗体 Fc 结构域上的α-半乳糖基化聚糖结合。
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本文引用的文献

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Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins.中国仓鼠卵巢细胞可在蛋白质上产生半乳糖-α-1,3-半乳糖抗原。
Nat Biotechnol. 2010 Nov;28(11):1153-6. doi: 10.1038/nbt1110-1153.
2
Anti-infliximab IgE and non-IgE antibodies and induction of infusion-related severe anaphylactic reactions.抗英夫利昔单抗 IgE 和非 IgE 抗体与输注相关严重过敏反应的诱导。
Allergy. 2010 May;65(5):657-61. doi: 10.1111/j.1398-9995.2009.02280.x. Epub 2009 Nov 27.
3
Mammalian meat-induced anaphylaxis: clinical relevance of anti-galactose-alpha-1,3-galactose IgE confirmed by means of skin tests to cetuximab.
过敏性疾病背景下针对组分变应原的抗体的同种型多样性：嗜酸性粒细胞性食管炎（EoE）、哮喘和α-半乳糖综合征（AGS）。
Front Allergy. 2025 Feb 4;5:1488857. doi: 10.3389/falgy.2024.1488857. eCollection 2024.
4
Alpha-Gal Syndrome: An Underrated Serious Disease and a Potential Future Challenge.α-半乳糖综合征：一种被低估的严重疾病及未来潜在挑战
Glob Chall. 2024 Jun 3;8(7):2300331. doi: 10.1002/gch2.202300331. eCollection 2024 Jul.
5
Basophil Activation Test Predicts Cetuximab Anaphylaxis Severity in Alpha-Gal IgE-Positive Patients.嗜碱性粒细胞活化试验可预测α-半乳糖IgE阳性患者西妥昔单抗过敏反应的严重程度。
Diagnostics (Basel). 2024 Jul 1;14(13):1403. doi: 10.3390/diagnostics14131403.
6
Combinatory glycoengineering of monoclonal antibodies and its application in cancer therapy: a narrative review.单克隆抗体的组合糖基工程及其在癌症治疗中的应用：一项叙述性综述
Transl Cancer Res. 2024 Feb 29;13(2):1150-1165. doi: 10.21037/tcr-23-1371. Epub 2024 Feb 21.
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Life (Basel). 2023 Mar 5;13(3):699. doi: 10.3390/life13030699.
哺乳动物肉类诱发的过敏反应：通过对西妥昔单抗进行皮肤试验证实的抗半乳糖-α-1,3-半乳糖 IgE 的临床相关性。
J Allergy Clin Immunol. 2009 Sep;124(3):603-5. doi: 10.1016/j.jaci.2009.06.014.
4
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J Allergy Clin Immunol. 2009 Feb;123(2):426-33. doi: 10.1016/j.jaci.2008.10.052. Epub 2008 Dec 13.
5
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6
Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequential enzymatic digestion.通过正交基质辅助激光解吸/电离混合四极杆-四极杆飞行时间串联质谱法与顺序酶切相结合对单克隆抗体西妥昔单抗上的N-连接寡糖进行结构表征
Anal Biochem. 2007 May 1;364(1):8-18. doi: 10.1016/j.ab.2007.01.023. Epub 2007 Jan 20.
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Selective clearance of glycoforms of a complex glycoprotein pharmaceutical caused by terminal N-acetylglucosamine is similar in humans and cynomolgus monkeys.由末端 N - 乙酰葡糖胺引起的复合糖蛋白药物糖型的选择性清除在人类和食蟹猴中相似。
Glycobiology. 2007 May;17(5):529-40. doi: 10.1093/glycob/cwm017. Epub 2007 Mar 1.
8
Glycosylation of recombinant antibody therapeutics.重组抗体治疗药物的糖基化
Biotechnol Prog. 2005 Jan-Feb;21(1):11-6. doi: 10.1021/bp040016j.
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Site-specific glycosylation of recombinant rat and human soluble CD4 variants expressed in Chinese hamster ovary cells.在中国仓鼠卵巢细胞中表达的重组大鼠和人可溶性CD4变体的位点特异性糖基化。
J Biol Chem. 1993 Feb 15;268(5):3260-7.
10
Transfer and expression of a murine UDP-Gal:beta-D-Gal-alpha 1,3-galactosyltransferase gene in transfected Chinese hamster ovary cells. Competition reactions between the alpha 1,3-galactosyltransferase and the endogenous alpha 2,3-sialyltransferase.鼠源UDP-半乳糖：β-D-半乳糖-α1,3-半乳糖基转移酶基因在转染的中国仓鼠卵巢细胞中的转移与表达。α1,3-半乳糖基转移酶与内源性α2,3-唾液酸转移酶之间的竞争反应。
J Biol Chem. 1990 Apr 15;265(11):6225-34.