Wanitphakdeedecha Rungsima, Eimpunth Sasima, Manuskiatti Woraphong
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Dermatol Res Pract. 2011;2011:807906. doi: 10.1155/2011/807906. Epub 2011 Jun 30.
Background. Mucopolysaccharide polysulphate (MPS) has been used in medicine as an anti-inflammatory and antithrombotic agent for over 50 years. Its chemical structure permits considerable hydrogen bonding with adjacent water molecules, which effectively leads to hydration of the surrounding tissue. In addition, it stimulates endogenous hyaluronate synthesis, resulting in an increase in water-binding capacity and viscoelasticity of the skin. Objective. To study the efficacy of 0.1% MPS on hydration and elasticity of human skin. Methods. The first part of this study was a randomized double blind placebo-controlled study which included 60 female volunteers aged 30-45 years with dry skin, defined by Corneometer CM 825. The volunteers were treated with either 0.1% MPS or vehicle control. All subjects were asked to apply 1 g of cream to their face twice daily for a total period of 4 weeks. Skin hydration and elasticity were measured at baseline and week 4 with Corneometer CM 825 and cutometer MPA 580, respectively, at forehead and both cheeks. The second part of this study focused on the efficacy of 0.1% MPS on skin hydration after single application. 20 female volunteers aged 30-45 years with dry skin, defined by Corneometer CM 825, were recruited to the study. All subjects were asked to apply 2 g of 0.1% MPS cream on entirely randomly selected forearm. Skin hydration at the middle of both forearms was measured at baseline, immediately after application, and every 1 hour after application for a period of 10 hours. Results. 57 subjects (28 in vehicle control group, 29 in MPS) completed treatment protocol. The baseline skin hydration of both groups was not significantly different (P = 0.47). Hower, there was a statistically significant difference in skin hydration at 4 weeks between MPS and placebo group (P = 0.01). Skin elasticity was significantly improved at week 4 in both groups (vehicle-control, P < 0.01, and MPS, P < 0.01). However, no significant difference in skin elasticity between MPS and vehicle-control group was noted (P = 0.15). Lastly, there was a statistically significant improvement in skin hydration after a single application (P < 0.01). This improvement was maintained for 10 hours. Conclusions. MPS provided improvement of skin hydration but not skin elasticity in woman with dry skin, compared with vehicle control. And MPS improved the skin hydration for at least 10 hours after single application.
背景。硫酸黏多糖（MPS）作为一种抗炎和抗血栓药物已在医学中使用了50多年。其化学结构允许与相邻水分子形成大量氢键，这有效地导致周围组织的水合作用。此外，它刺激内源性透明质酸的合成，导致皮肤的水结合能力和粘弹性增加。目的。研究0.1% MPS对人体皮肤水合作用和弹性的疗效。方法。本研究的第一部分是一项随机双盲安慰剂对照研究，纳入了60名年龄在30 - 45岁之间、皮肤干燥（由角质层水合测定仪CM 825定义）的女性志愿者。志愿者分别接受0.1% MPS或赋形剂对照治疗。所有受试者被要求每天两次在面部涂抹1克乳膏，共持续4周。分别在前额和双颊使用角质层水合测定仪CM 825和皮肤弹性测定仪MPA 580在基线和第4周测量皮肤水合作用和弹性。本研究的第二部分聚焦于单次应用0.1% MPS后对皮肤水合作用的疗效。招募了20名年龄在30 - 45岁之间、皮肤干燥（由角质层水合测定仪CM 825定义）的女性志愿者参与该研究。所有受试者被要求在完全随机选择的前臂上涂抹2克0.1% MPS乳膏。在基线、涂抹后立即以及涂抹后每1小时测量一次两个前臂中部的皮肤水合作用，持续10小时。结果。57名受试者（赋形剂对照组28名，MPS组29名）完成了治疗方案。两组的基线皮肤水合作用无显著差异（P = 0.47）。然而，MPS组和安慰剂组在第4周时皮肤水合作用存在统计学显著差异（P = 0.01）。两组在第4周时皮肤弹性均有显著改善（赋形剂对照组，P < 0.01；MPS组，P < 0.01）。然而，MPS组和赋形剂对照组之间的皮肤弹性无显著差异（P = 0.15）。最后，单次应用后皮肤水合作用有统计学显著改善（P < 0.01）。这种改善持续了10小时。结论。与赋形剂对照相比，MPS可改善干性皮肤女性的皮肤水合作用，但不能改善皮肤弹性。并且MPS单次应用后可使皮肤水合作用改善至少10小时。
