Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK.
Eur J Pediatr. 2012 Feb;171(2):281-7. doi: 10.1007/s00431-011-1525-3. Epub 2011 Jul 12.
Cardiovascular malformations are an important cause of infant death and the major cause of death due to malformation. Our aims were to analyse and categorise all deaths in infants with cardiovascular malformations, and to analyse trends in mortality over time and influences on mortality. We obtained details of infant deaths and cardiovascular malformations from the population of one health region for 1987-2006. We categorised deaths by cause and by presence of additional chromosomal or genetic abnormalities or non-cardiac malformations. In 676,927 live births the total infant mortality was 4,402 (6.5 per 1,000). A total of 4,437 infants had cardiovascular malformations (6.6 per 1000) of whom 458 (10.3%) died before 1 year of age. Of this number, 151 (33%) deaths had non-cardiac causes, 128 (28%) were cardiac without surgery and 179 (39%) occurred from cardiac causes after surgery. Death was unrelated to the cardiovascular malformation in 57% of infants with an additional chromosomal or genetic abnormality, in 76% of infants with a major non-cardiac malformation and in 16% of infants with an isolated cardiovascular malformation. Terminations of pregnancies affected by cardiovascular malformations increased from 20 per 100,000 registered births in the first 5 years to 78 per 100,000 in the last 5 years. A total of 2,067 infants (47%) underwent surgery and of these 216 (10%) died before 1 year of age.
A total of 10.4% of infants who died had a cardiovascular malformation and two-thirds of deaths were due to the malformation or its treatment. Mortality declined due to increasing termination of pregnancy and improved survival after operation.
心血管畸形是婴儿死亡的一个重要原因，也是畸形导致死亡的主要原因。我们的目的是分析和分类所有患有心血管畸形的婴儿死亡，并分析随时间推移死亡率的趋势以及死亡率的影响因素。我们从 1987 年至 2006 年的一个卫生区域的人群中获得了婴儿死亡和心血管畸形的详细信息。我们根据死因和是否存在额外的染色体或遗传异常或非心脏畸形对死亡进行分类。在 676927 例活产中，总婴儿死亡率为 4402（每 1000 例 6.5 例）。共有 4437 例婴儿患有心血管畸形（每 1000 例 6.6 例），其中 458 例（10.3%）在 1 岁之前死亡。在这一数字中，151 例（33%）死亡的非心脏原因，128 例（28%）为无手术的心脏原因，179 例（39%）为手术后心脏原因。在伴有额外染色体或遗传异常的婴儿中，57%的死亡与心血管畸形无关，在伴有主要非心脏畸形的婴儿中，76%的死亡与心血管畸形无关，在伴有孤立性心血管畸形的婴儿中，16%的死亡与心血管畸形无关。心血管畸形相关妊娠终止的数量从前 5 年的每 10 万例登记出生中增加了 20 例，到最后 5 年增加了 78 例。共有 2067 例婴儿（47%）接受了手术，其中 216 例（10%）在 1 岁之前死亡。
总共 10.4%的死亡婴儿患有心血管畸形，三分之二的死亡是由于畸形或其治疗。由于终止妊娠的增加和手术后存活率的提高，死亡率有所下降。
