Collins Caitlin, Nelson W James
Department of Biology, Stanford University, Stanford, CA 94305, USA.
Department of Biology, Stanford University, Stanford, CA 94305, USA.
Curr Opin Cell Biol. 2015 Oct;36:62-70. doi: 10.1016/j.ceb.2015.07.004. Epub 2015 Jul 17.
Coordinated movement of large groups of cells is required for many biological processes, such as gastrulation and wound healing. During collective cell migration, cell-cell and cell-extracellular matrix (ECM) adhesions must be integrated so that cells maintain strong interactions with neighboring cells and the underlying substratum. Initiation and maintenance of cadherin adhesions at cell-cell junctions and integrin-based cell-ECM adhesions require integration of mechanical cues, dynamic regulation of the actin cytoskeleton, and input from specific signaling cascades, including Rho family GTPases. Here, we summarize recent advances made in understanding the interplay between these pathways at cadherin-based and integrin-based adhesions during collective cell migration and highlight outstanding questions that remain in the field.
许多生物过程，如原肠胚形成和伤口愈合，都需要大量细胞的协调运动。在集体细胞迁移过程中，细胞间和细胞与细胞外基质（ECM）的粘附必须整合，以便细胞与相邻细胞和下层基质保持强烈的相互作用。细胞间连接处钙粘蛋白粘附的起始和维持以及基于整合素的细胞与ECM粘附需要整合机械信号、肌动蛋白细胞骨架的动态调节以及特定信号级联的输入，包括Rho家族GTP酶。在这里，我们总结了在理解集体细胞迁移过程中基于钙粘蛋白和基于整合素的粘附这些途径之间相互作用方面取得的最新进展，并强调了该领域仍然存在的突出问题。
