金黄色葡萄球菌环丙沙星耐药菌株中的DNA促旋酶gyrA突变：与大肠杆菌喹诺酮耐药突变极为相似。
DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli.
作者信息
Sreedharan S, Oram M, Jensen B, Peterson L R, Fisher L M
机构信息
Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, University of London, United Kingdom.
出版信息
J Bacteriol. 1990 Dec;172(12):7260-2. doi: 10.1128/jb.172.12.7260-7262.1990.
The gyrA genes isolated from three ciprofloxacin-resistant clinical isolates of Staphylococcus aureus carried codon 84 (serine----leucine) and/or codon 85 (serine----proline) mutations that were absent in pretreatment susceptible strains. These substitutions occur in a region of the gyrase A protein wherein directly analogous mutations of serine 83----leucine and alanine 84----proline in Escherichia coli confer quinolone resistance. Thus, DNA gyrase A subunit mutations are implicated in resistance to ciprofloxacin in S. aureus.
从三株耐环丙沙星的金黄色葡萄球菌临床分离株中分离出的gyrA基因携带84位密码子（丝氨酸→亮氨酸）和/或85位密码子（丝氨酸→脯氨酸）突变，而这些突变在治疗前的敏感菌株中不存在。这些替换发生在回旋酶A蛋白的一个区域，在该区域中，大肠杆菌中丝氨酸83→亮氨酸和丙氨酸84→脯氨酸的直接类似突变赋予喹诺酮抗性。因此，DNA回旋酶A亚基突变与金黄色葡萄球菌对环丙沙星的抗性有关。
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