Institut Pasteur, Unité des Interactions Bactéries-Cellules, Paris, France.
Biol Chem. 2011 Aug;392(8-9):831-5. doi: 10.1515/BC.2011.078. Epub 2011 Jul 13.
Many pathogens have evolved a variety of mechanisms to exploit the host-cell actin cytoskeleton during infection, either to enter into cells or to move within cells. These events have been investigated and documented in detail. Yet, a complete picture of the molecules and mechanisms regulating entry and intracellular movement remains to be established. Here we present a series of studies revealing that in addition to actin rearrangements the host cell also employs septins, a relatively newly characterized component of the cell cyto-skeleton, to regulate bacterial entry and restrict the dissemination of cytosolic bacteria. The challenge now is to decipher the precise role of septins during actin rearrangements and how these different cytoskeleton components orchestrate infection processes.
许多病原体在感染过程中进化出了多种利用宿主细胞肌动蛋白细胞骨架的机制，无论是进入细胞还是在细胞内移动。这些事件已经被详细研究和记录。然而，调节进入和细胞内运动的分子和机制的全貌仍有待建立。在这里，我们提出了一系列的研究结果，揭示了除了肌动蛋白重排外，宿主细胞还利用了 septin，这是细胞细胞骨架的一个相对新的组成部分，来调节细菌的进入并限制细胞质细菌的传播。现在的挑战是破译 septin 在肌动蛋白重排过程中的精确作用以及这些不同的细胞骨架成分如何协调感染过程。
