Department of Chemistry, BK School of Molecular Science, Polymer Research Institute, Pohang University of Science and Technology, Pohang, Korea.
Nucleic Acid Ther. 2011 Jun;21(3):133-47. doi: 10.1089/nat.2011.0293.
This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles. The article will provide a brief and concise account of underlying principle of these polymeric vectors and their structural and functional modifications which were intended to serve different purposes to affect efficient therapeutic outcome of small-interfering RNA delivery. The modifications of these polymeric vectors will be discussed with reference to stimuli-responsiveness, target specific delivery, and incorporation of nanoconstructs such as carbon nanotubes, gold nanoparticles, and silica nanoparticles. The emergence of small-interfering RNA as the potential therapeutic agent and its mode of action will also be mentioned in a nutshell.
这篇综述将涵盖目前正在采用的有效使用非病毒载体传递小干扰 RNA 的策略，包括使用聚合物如聚乙烯亚胺、聚（乳酸-共-乙醇酸）、多肽、壳聚糖、环糊精、树枝状聚合物和含有不同纳米粒子的聚合物。本文将简要介绍这些聚合物载体的基本原理及其结构和功能修饰，这些修饰旨在用于不同目的，以影响小干扰 RNA 传递的有效治疗结果。将参照刺激响应性、靶向特异性传递以及碳纳米管、金纳米粒子和硅纳米粒子等纳米结构的掺入来讨论这些聚合物载体的修饰。小干扰 RNA 作为潜在治疗剂及其作用模式也将简要提及。
