Ferrari A U, Daffonchio A, Albergati F, Bertoli P, Mancia G
Cattedra di Semeiotica Medica, Università di Milano, Italy.
J Hypertens. 1990 Oct;8(10):909-11. doi: 10.1097/00004872-199010000-00004.
The heating and restraint inherent to tail-cuff measurement of systolic blood pressure (SBP) in rats may alter SBP and introduce a 'biological' error in its estimation by this technique. This problem was examined in unanesthetized normotensive and hypertensive rats fitted with an arterial catheter. All SBP values recorded in unrestrained rats during a 2 h period were averaged by computer and compared with intra-arterial SBP measurements observed while the rat was being subjected to the tail-cuff procedure. With the latter procedure, SBP was 16 +/- 2 mmHg lower in normotensive rats (P less than 0.001) and 7 +/- 3 mmHg higher in hypertensive rats (P less than 0.05) than when the rats were unrestrained. The effects of heat and restraint, both separately and in combination, on SBP were evaluated during four additional 30-min monitoring periods. In both groups of rats, restraint failed to alter SBP and heat lowered it slightly. The two stimuli, combined, lowered SBP in normotensive rats, but raised it by 12 +/- 2 mmHg in hypertensive rats (P less than 0.01). Thus, tail-cuff SBP measurements represent under- and overestimates in normotensive and hypertensive rats, respectively, since the two groups respond to the procedure in opposite manners.
大鼠尾套法测量收缩压（SBP）时固有的加热和束缚可能会改变SBP，并通过该技术在其估计中引入“生物学”误差。在安装了动脉导管的未麻醉正常血压和高血压大鼠中研究了这个问题。计算机对无束缚大鼠在2小时内记录的所有SBP值进行平均，并与大鼠接受尾套法测量时观察到的动脉内SBP测量值进行比较。采用后一种方法时，正常血压大鼠的SBP比无束缚时低16±2 mmHg（P<0.001），高血压大鼠的SBP比无束缚时高7±3 mmHg（P<0.05）。在另外四个30分钟的监测期内，分别评估了热和束缚单独及联合作用对SBP的影响。在两组大鼠中，束缚均未改变SBP，热使其略有降低。两种刺激联合作用时，正常血压大鼠的SBP降低，但高血压大鼠的SBP升高了12±2 mmHg（P<0.01）。因此，尾套法测量的SBP在正常血压和高血压大鼠中分别代表低估和高估，因为两组对该操作的反应方式相反。
