Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Israel.
Curr Top Microbiol Immunol. 2012;353:145-62. doi: 10.1007/82_2011_147.
The first discoveries of mammalian A-to-I RNA editing have been serendipitous. In conjunction with the fast advancement in sequencing technology, systematic methods for prediction and detection of editing sites have been developed, leading to the discovery of thousands of A-to-I editing sites. Here we review the state-of-the-art of these methods and discuss future directions.
哺乳动物 A-to-I RNA 编辑的最初发现纯属偶然。随着测序技术的快速发展，预测和检测编辑位点的系统方法也相继被开发出来，从而发现了数千个 A-to-I 编辑位点。本文综述了这些方法的最新进展，并讨论了未来的发展方向。
