骨组织中 tenascin 表达的调控。
Regulation of tenascin expression in bone.
机构信息
Department of Anatomy, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA.
出版信息
J Cell Biochem. 2011 Nov;112(11):3354-63. doi: 10.1002/jcb.23265.
Abstract
Tenascins regulate cell interaction with the surrounding pericellular matrix. Within bone, tenascins C and W influence osteoblast adhesion and differentiation, although little is known about the regulation of tenascin expression. In this study we examined the effect of osteogenic differentiation, bone morphogenetic protein (BMP) and Wnt growth factors, and mechanical loading on tenascin expression in osteogenic cells. Osteogenic differentiation increased tenascin C (TnC), and decreased tenascin W (TnW), expression. Both growth factors and mechanical loading increased both TnC and TnW expression, albeit via distinct signaling mechanisms. Both BMP-2 and Wnt5a induction of tenascin expression were mediated by MAP kinases. These data establish a role for BMP, Wnts, and mechanical loading in the regulation of tenascin expression in osteoblasts.
摘要
纤连蛋白调节细胞与周围细胞外基质的相互作用。在骨骼中，纤连蛋白 C 和 W 影响成骨细胞的黏附和分化，尽管关于纤连蛋白表达的调控知之甚少。在这项研究中，我们研究了成骨分化、骨形态发生蛋白 (BMP) 和 Wnt 生长因子以及机械加载对成骨细胞中纤连蛋白表达的影响。成骨分化增加了纤连蛋白 C (TnC)，而降低了纤连蛋白 W (TnW) 的表达。两种生长因子和机械加载都增加了 TnC 和 TnW 的表达，尽管它们通过不同的信号机制。BMP-2 和 Wnt5a 诱导纤连蛋白表达都是通过 MAP 激酶介导的。这些数据确立了 BMP、Wnt 和机械加载在调节成骨细胞中纤连蛋白表达中的作用。
相似文献
1
Regulation of tenascin expression in bone.骨组织中 tenascin 表达的调控。
J Cell Biochem. 2011 Nov;112(11):3354-63. doi: 10.1002/jcb.23265.
2
Transcriptional regulation of tenascin genes.腱生蛋白基因的转录调控
Cell Adh Migr. 2015;9(1-2):34-47. doi: 10.1080/19336918.2015.1008333.
3
Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells.骨形态发生蛋白、细胞外基质和丝裂原活化蛋白激酶信号通路是MC3T3-E1细胞中骨细胞特异性基因表达和分化所必需的。
J Bone Miner Res. 2002 Jan;17(1):101-10. doi: 10.1359/jbmr.2002.17.1.101.
4
Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells.结缔组织生长因子（CTGF）在间充质干细胞向成骨细胞分化过程中受Wnt和骨形态发生蛋白信号通路的调控。
J Biol Chem. 2004 Dec 31;279(53):55958-68. doi: 10.1074/jbc.M407810200. Epub 2004 Oct 20.
5
Activation of p38 and Smads mediates BMP-2 effects on human trabecular bone-derived osteoblasts.p38和Smads的激活介导了骨形态发生蛋白-2对人小梁骨来源成骨细胞的作用。
Exp Cell Res. 2003 Nov 15;291(1):201-11. doi: 10.1016/s0014-4827(03)00386-0.
6
Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts.Wnt与骨形态发生蛋白2（BMP-2）信号在C2C12成肌细胞分化途径中的相互作用。
J Biol Chem. 2005 Nov 11;280(45):37660-8. doi: 10.1074/jbc.M504612200. Epub 2005 Sep 2.
7
Induction of vascular smooth muscle cell tenascin-C gene expression by denatured type I collagen is dependent upon a beta3 integrin-mediated mitogen-activated protein kinase pathway and a 122-base pair promoter element.变性I型胶原诱导血管平滑肌细胞肌腱蛋白-C基因表达依赖于β3整合素介导的丝裂原活化蛋白激酶途径和一个122个碱基对的启动子元件。
J Cell Sci. 1999 Feb;112 ( Pt 4):435-45. doi: 10.1242/jcs.112.4.435.
8
Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF).骨形态发生蛋白（BMP）-4 和 BMP-7 对正常肺成纤维细胞（NHLF）中的转化生长因子（TGF）-β1 有不同的调节作用。
Respir Res. 2010 Jun 23;11(1):85. doi: 10.1186/1465-9921-11-85.
9
The LIM-only protein FHL2 controls mesenchymal cell osteogenic differentiation and bone formation through Wnt5a and Wnt10b.LIM 仅蛋白 FHL2 通过 Wnt5a 和 Wnt10b 控制间充质细胞成骨分化和骨形成。
Bone. 2013 Mar;53(1):6-12. doi: 10.1016/j.bone.2012.11.020. Epub 2012 Nov 29.
10
Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms.前列腺癌通过Wnt诱导的骨形态发生蛋白依赖性和非依赖性机制诱发骨转移。
Cancer Res. 2008 Jul 15;68(14):5785-94. doi: 10.1158/0008-5472.CAN-07-6541.
引用本文的文献
1
Decoding Cellular Communication Networks and Signaling Pathways in Bone, Skeletal Muscle, and Bone-Muscle Crosstalk Through Spatial Transcriptomics.通过空间转录组学解码骨骼、骨骼肌以及骨-肌相互作用中的细胞通讯网络和信号通路
Res Sq. 2025 Jun 12:rs.3.rs-6701121. doi: 10.21203/rs.3.rs-6701121/v1.
2
A Systematic Review of the Effects of Bisphosphonates on Osteoblasts In Vitro.双膦酸盐对体外成骨细胞作用的系统评价
Calcif Tissue Int. 2025 Jun 16;116(1):86. doi: 10.1007/s00223-025-01390-w.
3
Testosterone Delays Bone Microstructural Destruction via Osteoblast-Androgen Receptor-Mediated Upregulation of Tenascin-C.睾酮通过成骨细胞-雄激素受体介导的腱生蛋白-C上调延缓骨微结构破坏。
Adv Sci (Weinh). 2025 Aug;12(31):e01518. doi: 10.1002/advs.202501518. Epub 2025 May 30.
4
Live Cell Sorting of Differentiated Primary Human Osteoclasts Allows Generation of Transcriptomic Signature Matrix.分化的原代人破骨细胞的活细胞分选可生成转录组特征矩阵。
Res Sq. 2025 Apr 1:rs.3.rs-6157400. doi: 10.21203/rs.3.rs-6157400/v1.
5
A proteomics approach to study mouse long bones: examining baseline differences and mechanical loading-induced bone formation in young-adult and old mice.一种研究小鼠长骨的蛋白质组学方法：研究青年期和成长期小鼠的基线差异和机械加载诱导的骨形成。
Aging (Albany NY). 2024 Oct 12;16(19):12726-12768. doi: 10.18632/aging.206131.
6
Single-cell RNA sequencing reveals cellular and molecular heterogeneity in fibrocartilaginous enthesis formation.单细胞 RNA 测序揭示纤维软骨结合处形成中的细胞和分子异质性。
Elife. 2023 Sep 12;12:e85873. doi: 10.7554/eLife.85873.
7
Differential gene expression in the calvarial and cortical bone of juvenile female mice.幼年雌性小鼠颅骨和皮质骨中的差异基因表达。
Front Endocrinol (Lausanne). 2023 Jun 12;14:1127536. doi: 10.3389/fendo.2023.1127536. eCollection 2023.
8
Integrated spatiotemporal transcriptomic resolution of embryonic palate osteogenesis.胚胎腭骨生成的综合时空转录组学解析
bioRxiv. 2023 Mar 30:2023.03.30.534875. doi: 10.1101/2023.03.30.534875.
9
Androgen receptor variant-7 regulation by tenascin-c induced src activation.腱糖蛋白 C 诱导 src 激活对雄激素受体变体-7 的调控。
Cell Commun Signal. 2022 Aug 10;20(1):119. doi: 10.1186/s12964-022-00925-0.
10
Revisiting the Tenascins: Exploitable as Cancer Targets?重新审视腱糖蛋白：可用作癌症靶点吗？
Front Oncol. 2022 Jun 17;12:908247. doi: 10.3389/fonc.2022.908247. eCollection 2022.
本文引用的文献
1
Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts.机械应力通过 PKCδ 激活 Smad 通路，增强成骨细胞中白细胞介素-11 基因的转录。
PLoS One. 2010 Sep 29;5(9):e13090. doi: 10.1371/journal.pone.0013090.
2
Hypoxia increases Annexin A2 expression in osteoblastic cells via VEGF and ERK.缺氧通过 VEGF 和 ERK 增加成骨细胞中 Annexin A2 的表达。
Bone. 2010 Dec;47(6):1013-9. doi: 10.1016/j.bone.2010.08.024. Epub 2010 Sep 15.
3
Differential gene expression in classic giant cell tumours of bone: Tenascin C as biological risk factor for local relapses and metastases.经典骨巨细胞瘤中的差异基因表达：Tenascin C 作为局部复发和转移的生物学风险因素。
Histopathology. 2010 Jul;57(1):59-72. doi: 10.1111/j.1365-2559.2010.03597.x.
4
Purinergic signalling and bone remodelling.嘌呤能信号转导与骨重建。
Curr Opin Pharmacol. 2010 Jun;10(3):322-30. doi: 10.1016/j.coph.2010.01.003. Epub 2010 Feb 25.
5
The role of endogenous bone morphogenetic proteins in normal skeletal repair.内源性骨形态发生蛋白在正常骨骼修复中的作用。
Injury. 2009 Dec;40 Suppl 3:S4-7. doi: 10.1016/S0020-1383(09)70003-8.
6
Bone morphogenetic proteins in orthopaedic surgery.骨形成蛋白在骨科手术中的应用。
Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):481-8. doi: 10.1016/j.cytogfr.2009.10.003. Epub 2009 Nov 4.
7
Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway.Wnt信号通路通过腱生蛋白C/血小板衍生生长因子受体途径调节小鼠肺中平滑肌前体细胞的发育。
J Clin Invest. 2009 Sep;119(9):2538-49. doi: 10.1172/JCI38079. Epub 2009 Aug 17.
8
Wnt signaling during fracture repair.骨折修复过程中的Wnt信号传导。
Curr Osteoporos Rep. 2009 Jul;7(2):64-9. doi: 10.1007/s11914-009-0012-5.
9
Association of tenascin-W expression with mineralization in mouse calvarial development.肌腱蛋白-W表达与小鼠颅骨发育中矿化的关联
Congenit Anom (Kyoto). 2009 Jun;49(2):77-84. doi: 10.1111/j.1741-4520.2009.00227.x.
10
Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate.非经典Wnt信号通路和与N-钙黏蛋白相关的β-连环蛋白信号通路在机械诱导的成骨细胞命运中发挥作用。
PLoS One. 2009;4(4):e5388. doi: 10.1371/journal.pone.0005388. Epub 2009 Apr 29.
Zotero 插件