Anghelescu Doralina L, Rakes Lauren C, Shearer Jack R, Bikhazi George B
Pain Management Service, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
AANA J. 2011 Jun;79(3):238-42.
Emergence agitation (EA) can be a distressing side effect of pediatric anesthesia. We retrospectively reviewed the records of 7 pediatric oncology patients who received low-dose ketamine in conjunction with propofol for total intravenous anesthesia (TIVA) repeatedly for radiation therapy. EA signs were observed in all 7 patients in association with propofol TIVA but did not recur in any of 123 subsequent anesthetics sessions during which low-dose ketamine was added to propofol. Based on this experience, we suggest that low-dose ketamine added to propofol may be associated with prevention of EA in children with a history of EA with propofol TIVA.
苏醒期躁动（EA）可能是小儿麻醉令人苦恼的副作用。我们回顾性分析了7例儿科肿瘤患者的记录，这些患者在接受放射治疗时多次接受低剂量氯胺酮联合丙泊酚用于全静脉麻醉（TIVA）。在所有7例患者接受丙泊酚TIVA时均观察到EA征象，但在随后123次麻醉过程中，当在丙泊酚中添加低剂量氯胺酮时，EA征象均未复发。基于这一经验，我们认为在有丙泊酚TIVA所致EA病史的儿童中，丙泊酚添加低剂量氯胺酮可能与预防EA有关。
