Auerbach O, Garfinkel L, Parks V R
Cancer. 1979 Feb;43(2):636-42. doi: 10.1002/1097-0142(197902)43:2<636::aid-cncr2820430234>3.0.co;2-7.
In a review of 1,186 cases of lung cancer found amoung 7,629 autopsied cases over a 21 year period a total of 82 peripheral cancers related to scars were found, constituting 1% of the autopsied cases and 7% of the lung tumors. 15% of all lung tumors were peripheral (vs. bronchogenic) and the percentage rose from less than 7 in the time period of 1955 to 1960 to a little more than 23 in the 1970 to 1976 time period. 45% of all peripheral lung cancers originated in a scar. Less than 2% of all lung cancers were found associated with scars in the 1955 through 1959 time period. This increased to nearly 16% in the 1970 through 1975 time period. 72% of the scar cancers were adenocarcinomas and 18% were of squamous cell type. The rest were large cell undifferentiated carcinomas and none was oat cell or small cell type. Over three-quarters of these scar cancers were found in the upper lobes and more than half were related to infarcts. Less than a quarter were related to tuberculosis scars. No relationship was found between smoking habits and scar cancer.
在对21年间7629例尸检病例中发现的1186例肺癌进行的回顾中，共发现82例与瘢痕相关的周围型癌，占尸检病例的1%，占肺肿瘤的7%。所有肺肿瘤的15%为周围型（相对于支气管源性），这一比例从1955年至1960年期间的不到7%上升至1970年至1976年期间的略高于23%。所有周围型肺癌的45%起源于瘢痕。在1955年至1959年期间，所有肺癌中不到2%与瘢痕有关。在1970年至1975年期间，这一比例增至近16%。瘢痕癌的72%为腺癌，18%为鳞状细胞型。其余为大细胞未分化癌，无燕麦细胞或小细胞型。这些瘢痕癌中超过四分之三位于上叶，一半以上与梗死有关。不到四分之一与结核瘢痕有关。未发现吸烟习惯与瘢痕癌之间存在关联。
