Parés A, Barrera J M, Caballería J, Ercilla G, Bruguera M, Caballería L, Castillo R, Rodés J
Liver Unit, University of Barcelona, Spain.
Hepatology. 1990 Dec;12(6):1295-9. doi: 10.1002/hep.1840120608.
The prevalence of hepatitis C virus antibody and its relationship to the severity of liver disease in chronic alcoholic patients has been assessed, using a recently developed enzyme immunoassay and confirmed by a recombinant immunoblot assay, in 144 patients (mean age +/- S.D. = 44.4 +/- 11.3 yr) who had consumed greater than 80 gm/day ethanol for greater than 5 yr. Hepatic disease was evaluated by clinical and biochemical studies and by liver biopsy when appropriate. In addition, 76 liver biopsy specimens from these patients were analyzed to determine whether liver lesions were similar in alcoholic patients with and without hepatitis C virus antibodies. According to clinical and histological features alcoholic patients were divided into five groups: normal liver (45 patients), fibrosteatosis (20 patients), alcoholic hepatitis (14 patients), cirrhosis (61 patients) and chronic hepatitis (4 patients). Hepatitis C virus antibodies were present in 35 alcoholic patients (24.3%). The prevalence of hepatitis C virus antibodies correlated with the severity of liver injury: 2.2% in patients without liver disease, 20% in those with fibrosteatosis, 41.4% in those with alcoholic hepatitis and 42.6% in those with cirrhosis. Hepatitis C virus antibodies were found in one of the four patients with chronic hepatitis (p less than 0.001). Furthermore, patients positive for hepatitis C virus antibodies with normal liver or fibrosteatosis showed higher serum bilirubin and gamma-globulin concentrations and lower aminopyrine breath test scores than did patients negative for hepatitis C virus antibodies with normal liver or fibrosteatosis. Similar differences between patients with and without hepatitis C virus antibodies were observed in patients with alcoholic hepatitis or cirrhosis.(ABSTRACT TRUNCATED AT 250 WORDS)
运用一种最新研发的酶免疫测定法，并通过重组免疫印迹法加以确认，对144名慢性酒精性肝病患者（平均年龄±标准差=44.4±11.3岁）进行了丙型肝炎病毒抗体的流行情况及其与肝病严重程度关系的评估。这些患者每日乙醇摄入量超过80克，饮酒时间超过5年。通过临床和生化研究以及必要时的肝活检来评估肝脏疾病。此外，对这些患者的76份肝活检标本进行分析，以确定有或无丙型肝炎病毒抗体的酒精性肝病患者的肝脏病变是否相似。根据临床和组织学特征，将酒精性肝病患者分为五组：正常肝脏（45例）、纤维脂肪变性（20例）、酒精性肝炎（14例）、肝硬化（61例）和慢性肝炎（4例）。35例酒精性肝病患者（24.3%）存在丙型肝炎病毒抗体。丙型肝炎病毒抗体的流行率与肝损伤的严重程度相关：无肝病患者中为2.2%，纤维脂肪变性患者中为20%，酒精性肝炎患者中为41.4%，肝硬化患者中为42.6%。4例慢性肝炎患者中有1例发现丙型肝炎病毒抗体（P<0.001）。此外，肝脏正常或有纤维脂肪变性的丙型肝炎病毒抗体阳性患者，其血清胆红素和γ-球蛋白浓度高于肝脏正常或有纤维脂肪变性的丙型肝炎病毒抗体阴性患者，氨基比林呼气试验得分更低。在酒精性肝炎或肝硬化患者中，有或无丙型肝炎病毒抗体的患者之间也观察到了类似差异。（摘要截选至250字）
