O'Brien I M, Newman-Taylor A J, Burge P S, Harries M G, Fawcett I W, Pepys J
Clin Allergy. 1979 Jan;9(1):7-15. doi: 10.1111/j.1365-2222.1979.tb01517.x.
In sixty-three workers exposed to toluene di-isocyanate (TDI), no overall differences in bronchial reactivity to histamine inhalation and to exercise testing were found between the total groups of positive and negative TDI reactors to provocation tests. A subgroup of TDI highly sensitive subjects reacting to very low concentrations (less than or equal to 0.001 p.p.m.) were more sensitive to both histamine and exercise than the group who were less sensitive to TDI, and who reacted to higher concentrations (0.002--0.02 p.p.m.) than the group of non-reactors. There were, however, in the last group a number of subjects with high degrees of histamine reactivity who did not react to the TDI. These findings suggest that, on the one hand, the asthmatic reactions to TDI cannot be attributed solely to non-specific mechanisms and, on the other, that in subjects with high degrees of specific sensitivity non-specific mechanisms may also be playing a part.
在63名接触甲苯二异氰酸酯（TDI）的工人中，对激发试验TDI反应阳性和阴性的总人群之间，在吸入组胺和运动试验的支气管反应性方面未发现总体差异。对极低浓度（小于或等于0.001 ppm）有反应的TDI高度敏感亚组，比那些对TDI不太敏感且对较高浓度（0.002 - 0.02 ppm）有反应的组，对组胺和运动更敏感。然而，在最后一组中有一些组胺反应性高但对TDI无反应的受试者。这些发现表明，一方面，对TDI的哮喘反应不能仅归因于非特异性机制，另一方面，在具有高度特异性敏感性的受试者中，非特异性机制也可能起作用。
