接触甲苯二异氰酸酯后持续性反应性气道功能障碍综合征
Persistent reactive airway dysfunction syndrome after exposure to toluene diisocyanate.
作者信息
Luo J C, Nelsen K G, Fischbein A
机构信息
Department of Community Medicine, Mount Sinai School of Medicine, City University of New York, New York 10029.
出版信息
Br J Ind Med. 1990 Apr;47(4):239-41. doi: 10.1136/oem.47.4.239.
Abstract
Two police officers developed asthma like illness after a single but prolonged exposure to toluene diisocyanate (TDI) by being in the immediate vicinity of a tank car that had overturned on a highway. One officer experienced upper and lower respiratory tract symptoms with chest tightness about 4.5 hours after initial exposure. Shortness of breath, cough, and wheezing were noted the following day. The other experienced symptoms immediately on exposure, developed shortness of breath 20 minutes later, and presented with wheezing four hours after that. Follow up examinations over seven years showed persistence of respiratory symptoms and continuation of airway hyperreactivity requiring treatment.
摘要
两名警察在高速公路上一辆罐车翻车后，因在罐体附近单次长时间接触甲苯二异氰酸酯（TDI）而患上类似哮喘的疾病。一名警察在初次接触约4.5小时后出现上、下呼吸道症状并伴有胸闷。次日出现呼吸急促、咳嗽和喘息。另一名警察在接触后立即出现症状，20分钟后出现呼吸急促，此后4小时出现喘息。七年的随访检查显示呼吸道症状持续存在，气道高反应性持续存在且需要治疗。
相似文献
1
Persistent reactive airway dysfunction syndrome after exposure to toluene diisocyanate.接触甲苯二异氰酸酯后持续性反应性气道功能障碍综合征
Br J Ind Med. 1990 Apr;47(4):239-41. doi: 10.1136/oem.47.4.239.
2
Persistent airways disease caused by toluene diisocyanate.由甲苯二异氰酸酯引起的持续性气道疾病。
Am Rev Respir Dis. 1986 Jul;134(1):175-6. doi: 10.1164/arrd.1986.134.1.175.
3
Toluene diisocyanate-induced asthma without airway hyperresponsiveness.甲苯二异氰酸酯诱发的无气道高反应性的哮喘
Eur J Respir Dis. 1986 Feb;68(2):89-95.
4
Recurrent asthma induced by toluene diisocyanate.甲苯二异氰酸酯诱发的复发性哮喘
Thorax. 1988 Aug;43(8):660-2. doi: 10.1136/thx.43.8.660.
5
TDI-induced oculorhinitis and bronchial asthma.
J Occup Med. 1985 Jan;27(1):51-2.
6
Occupational asthma due to toluene diisocyanate among velcro-like tape manufacturers.
Am J Ind Med. 1988;14(1):73-8. doi: 10.1002/ajim.4700140109.
7
[Diseases caused by diisocyanates. 2. Diisocyanate asthma].[二异氰酸酯所致疾病。2. 二异氰酸酯哮喘]
Derm Beruf Umwelt. 1979;27(1):5-10.
8
Chronic asthma due to toluene diisocyanate.甲苯二异氰酸酯所致的慢性哮喘
Chest. 1986 Oct;90(4):494-9. doi: 10.1378/chest.90.4.494.
9
Toluene diisocyanate respiratory reactions. I. Reassessment of the problem.甲苯二异氰酸酯的呼吸道反应。I. 问题的重新评估。
Int Arch Allergy Appl Immunol. 1987;84(1):93-100. doi: 10.1159/000234404.
10
Persistent asthma due to isocyanates. A follow-up study of subjects with occupational asthma due to toluene diisocyanate (TDI).异氰酸酯所致的持续性哮喘。一项针对甲苯二异氰酸酯（TDI）所致职业性哮喘患者的随访研究。
Am Rev Respir Dis. 1988 Jun;137(6):1326-9. doi: 10.1164/ajrccm/137.6.1326.
引用本文的文献
1
Exposure of Toluene Diisocyanate Induces DUSP6 and p53 through Activation of TRPA1 Receptor.甲苯二异氰酸酯暴露通过激活 TRPA1 受体诱导 DUSP6 和 p53。
Int J Mol Sci. 2022 Jan 4;23(1):517. doi: 10.3390/ijms23010517.
2
Isocyanates and work-related asthma: Findings from California, Massachusetts, Michigan, and New Jersey, 1993-2008.异氰酸酯与职业性哮喘：1993 - 2008年加利福尼亚州、马萨诸塞州、密歇根州和新泽西州的调查结果
Am J Ind Med. 2015 Nov;58(11):1138-49. doi: 10.1002/ajim.22527. Epub 2015 Sep 9.
3
Bronchial asthma and COPD due to irritants in the workplace - an evidence-based approach.工作场所刺激物导致的支气管哮喘和 COPD——一种基于证据的方法。
J Occup Med Toxicol. 2012 Sep 26;7(1):19. doi: 10.1186/1745-6673-7-19.
4
Respiratory irritants encountered at work.工作中遇到的呼吸道刺激物。
Thorax. 1996 May;51(5):541-5. doi: 10.1136/thx.51.5.541.
5
Survey of construction workers repeatedly exposed to chlorine over a three to six month period in a pulpmill: II. Follow up of affected workers by questionnaire, spirometry, and assessment of bronchial responsiveness 18 to 24 months after exposure ended.对造纸厂中在三到六个月期间反复接触氯气的建筑工人的调查：II. 接触结束18至24个月后，通过问卷调查、肺活量测定和支气管反应性评估对受影响工人进行随访。
Occup Environ Med. 1994 Apr;51(4):225-8. doi: 10.1136/oem.51.4.225.
6
Survey of construction workers repeatedly exposed to chlorine over a three to six month period in a pulpmill: I. Exposure and symptomatology.在一家纸浆厂对连续三到六个月反复接触氯的建筑工人进行的调查：I. 接触情况与症状学
Occup Environ Med. 1994 Apr;51(4):219-24. doi: 10.1136/oem.51.4.219.
7
Bronchial hyperreactivity in potroom workers and prognosis after stopping exposure.电解铝厂工人的支气管高反应性及停止接触后的预后
Br J Ind Med. 1991 Oct;48(10):653-5. doi: 10.1136/oem.48.10.653.
本文引用的文献
1
Pulmonary Changes Following Exposure to Phosgene.光气暴露后的肺部变化
Am J Pathol. 1947 Sep;23(5):679-93.
2
Bronchial hyperreactivity.支气管高反应性
Am Rev Respir Dis. 1980 Feb;121(2):389-413. doi: 10.1164/arrd.1980.121.2.389.
3
Induction of bronchial hypersensitivity: evidence for a role for prostaglandins.支气管超敏反应的诱导：前列腺素作用的证据
Thorax. 1981 Aug;36(8):571-4. doi: 10.1136/thx.36.8.571.
4
Isocyanate-induced pulmonary diseases: a current perspective.
J Allergy Clin Immunol. 1982 Jul;70(1):24-31. doi: 10.1016/0091-6749(82)90197-x.
5
Bronchial response to beta-adrenergic blockade.支气管对β-肾上腺素能阻滞剂的反应。
N Engl J Med. 1966 Sep 15;275(11):580-4. doi: 10.1056/NEJM196609152751103.
6
Recent occupational health experiences in Ontario.安大略省近期的职业健康经历。
J Occup Med. 1965 Oct;7(10):502-11.
7
Pulmonary toxicity of isocyanates.异氰酸酯的肺部毒性。
Ann Intern Med. 1970 Oct;73(4):654-5. doi: 10.7326/0003-4819-73-4-654.
8
Reactive airways dysfunction syndrome (RADS). Persistent asthma syndrome after high level irritant exposures.反应性气道功能障碍综合征（RADS）。高浓度刺激性物质暴露后出现的持续性哮喘综合征。
Chest. 1985 Sep;88(3):376-84. doi: 10.1378/chest.88.3.376.
9
Respiratory effects of inhaled isocyanates.吸入异氰酸酯的呼吸效应。
Crit Rev Toxicol. 1986;16(4):349-79. doi: 10.3109/10408448609037467.
10
Persistent asthma due to isocyanates. A follow-up study of subjects with occupational asthma due to toluene diisocyanate (TDI).异氰酸酯所致的持续性哮喘。一项针对甲苯二异氰酸酯（TDI）所致职业性哮喘患者的随访研究。
Am Rev Respir Dis. 1988 Jun;137(6):1326-9. doi: 10.1164/ajrccm/137.6.1326.
Zotero 插件