Hayakawa N, Morita T, Yamaguchi T, Mitsui H, Mori K J, Saisu H, Abe T
Department of Neurochemistry, Faculty of Science, Niigata University, Japan.
Biochem Biophys Res Commun. 1990 Dec 14;173(2):483-90. doi: 10.1016/s0006-291x(05)80059-2.
A monoclonal antibody recognizing the alpha 2 delta complex of the dihydropyridine (DHP)-sensitive calcium channel of skeletal muscle immunoprecipitated most of the DHP receptor solubilized from bovine and rabbit brains, and bovine cardiac muscle. However, it did not significantly immunoprecipitate the high affinity omega-conotoxin receptor solubilized from these brains. These results indicate that the DHP receptor and the high affinity omega-conotoxin receptor are different molecules in mammalian brain.
一种识别骨骼肌二氢吡啶（DHP）敏感性钙通道α2δ复合体的单克隆抗体，能免疫沉淀从牛脑、兔脑及牛心肌中溶解出来的大部分DHP受体。然而，它并不能显著免疫沉淀从这些脑组织中溶解出来的高亲和力ω-芋螺毒素受体。这些结果表明，在哺乳动物脑中，DHP受体和高亲和力ω-芋螺毒素受体是不同的分子。
