Ma Min-min, Yin Qin, Xu Ge-lin, Zhang Ren-liang, Zhu Shuang-gen, Fan Xin-ying, Zhu Wu-sheng, Liu Xin-feng
Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, China.
Zhonghua Yi Xue Za Zhi. 2011 May 24;91(19):1303-7.
To analyze the predictors of Wingspan in-stent restenosis (ISR) for the treatment of symptomatic intracranial arterial stenosis.
Between January 2007 and November 2009, 42 patients with symptomatic intracranial arterial stenosis registered in Nanjing stroke registry program (NSRP) were treated with Wingspan stent system. Clinical and follow-up results were retrospectively analyzed. They were divided into the non-restenosis and restenosis groups according to their follow-up imaging data. ISR was defined as > 50% stenosis within 5 mm or adjacent to stent or an absolute luminal loss > 20%. The analysis of stepwise multivariate Cox regression was performed to evaluate the independent predictive factors.
ISR was found in 15 patients (15/42, 35.7%) with 16 lesions (16/43, 37.2%) at a median follow-up period of 7 months (range: 4 - 23). Diabetes (HR = 0.281; 95%CI = 0.088 - 0.898; P = 0.032) and stent diameter (HR = 0.213; 95%CI = 0.049 - 0.918; P = 0.038) were two independent predictors for ISR.
Diabetes and stent diameter may be two independent predictors for ISR after a treatment of Wingspan system.
分析使用Wingspan支架治疗有症状的颅内动脉狭窄时支架内再狭窄（ISR）的预测因素。
2007年1月至2009年11月期间，对南京卒中登记项目（NSRP）中登记的42例有症状的颅内动脉狭窄患者采用Wingspan支架系统进行治疗。对临床和随访结果进行回顾性分析。根据随访影像资料将患者分为无再狭窄组和再狭窄组。ISR定义为支架内或支架附近5mm范围内狭窄>50%或绝对管腔丢失>20%。采用逐步多因素Cox回归分析评估独立预测因素。
15例患者（15/42，35.7%）出现ISR，共16处病变（16/43，37.2%），中位随访时间为7个月（范围：4 - 23个月）。糖尿病（HR = 0.281；95%CI = 0.088 - 0.898；P = 0.032）和支架直径（HR = 0.213；95%CI = 0.049 - 0.918；P = 0.038）是ISR的两个独立预测因素。
糖尿病和支架直径可能是Wingspan系统治疗后ISR的两个独立预测因素。
