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聚合物纳米杂化材料和功能化碳纳米管作为癌症治疗的药物输送载体。

Polymeric nanohybrids and functionalized carbon nanotubes as drug delivery carriers for cancer therapy.

机构信息

Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

出版信息

Adv Drug Deliv Rev. 2011 Nov;63(14-15):1340-51. doi: 10.1016/j.addr.2011.06.013. Epub 2011 Jul 3.

Abstract

The scope of nanotechnology to develop target specific carriers to achieve higher therapeutic efficacy is gaining importance in the pharmaceutical and other industries. Specifically, the emergence of nanohybrid materials is posed to edge over chemotherapy and radiation therapy as cancer therapeutics. This is primarily because nanohybrid materials engage controlled production parameters in the making of engineered particles with specific size, shape, and other essential properties. It is widely expressed that these materials will significantly contribute to the next generation of medical care technology and pharmaceuticals in areas of disease diagnosis, disease prevention and many other treatment procedures. This review focuses on the currently used nanohybrid materials, polymeric nanoparticles and nanotubes, which show great potential as effective drug delivery systems for cancer therapy, as they can be grafted with cell-specific receptors and intracellular targeting molecules for the targeted delivery of therapeutics. Specifically, this article focuses on the current status, recent advancements, potentials and limitations of polymeric nanohybrids and functionalized carbon nanotubes as drug delivery carriers.

摘要

纳米技术的应用范围包括开发靶向载体以实现更高的治疗效果,这在制药和其他行业中变得越来越重要。具体来说,纳米杂化材料的出现有望超越化疗和放疗成为癌症治疗的手段。这主要是因为纳米杂化材料在制造具有特定大小、形状和其他必要特性的工程颗粒时,可以控制生产参数。人们普遍认为,这些材料将为疾病诊断、疾病预防和许多其他治疗程序领域的下一代医疗保健技术和药物做出重大贡献。本综述重点介绍了目前使用的纳米杂化材料,即聚合物纳米粒子和纳米管,它们作为癌症治疗的有效药物递送系统具有巨大的潜力,因为它们可以与细胞特异性受体和细胞内靶向分子接枝,以实现治疗药物的靶向递送。具体来说,本文重点介绍了聚合物纳米杂化物和功能化碳纳米管作为药物递送载体的现状、最新进展、潜力和局限性。

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