Sawamura Y, Diserens A C, de Tribolet N
Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
J Neurooncol. 1990 Oct;9(2):125-30. doi: 10.1007/BF02427832.
Glioblastoma cells constitutively produce various amounts of PGE2 (prostaglandin E2) in vitro. The amounts of PGE2 found in the conditioned medium of the glioblastoma cultures (less than 5 ng/ml) were not enough to inhibit the IL-2 (interleukin-2) activation of peripheral blood lymphocytes. However the amount of PGE2 produced by approximately 1 x 10(7) of the glioblastoma cells can be assumed to suppress the generation of IL-2-induced killing activity against glioblastoma cells.
胶质母细胞瘤细胞在体外持续产生不同量的前列腺素E2（PGE2）。在胶质母细胞瘤培养物的条件培养基中发现的PGE2量（小于5 ng/ml）不足以抑制外周血淋巴细胞的白细胞介素-2（IL-2）激活。然而，可以假定约1×10⁷个胶质母细胞瘤细胞产生的PGE2量能够抑制IL-2诱导的针对胶质母细胞瘤细胞的杀伤活性的产生。
