Bartoli Kristen M, Bishop Darryl L, Saunders William S
Department of Biological Sciences, University of Pittsburgh, 4249 5th Avenue, Crawford Hall 274, Pittsburgh, PA 15213, USA.
Int J Cell Biol. 2011;2011:939848. doi: 10.1155/2011/939848. Epub 2011 Jun 20.
Stress granules (SGs) are cytoplasmic foci that appear in cells exposed to stress-induced translational inhibition. SGs function as a triage center, where mRNAs are sorted for storage, degradation, and translation reinitiation. The underlying mechanisms of SGs dynamics are still being characterized, although many key players have been identified. The main components of SGs are stalled 48S preinitiation complexes. To date, many other proteins have also been found to localize in SGs and are hypothesized to function in SG dynamics. Most recently, the microtubule cytoskeleton and associated motor proteins have been demonstrated to function in SG dynamics. In this paper, we will discuss current literature examining the function of microtubules and the molecular microtubule motors in SG assembly, coalescence, movement, composition, organization, and disassembly.
应激颗粒（SGs）是细胞质中的聚集区，出现在受到应激诱导的翻译抑制的细胞中。SGs作为一个分拣中心，在那里对信使核糖核酸（mRNAs）进行分类，以便储存、降解和重新启动翻译。尽管已经确定了许多关键因素，但SGs动态变化的潜在机制仍在研究之中。SGs的主要成分是停滞的48S起始前复合物。迄今为止，还发现许多其他蛋白质定位于SGs中，并被推测在SGs动态变化中发挥作用。最近，已经证明微管细胞骨架和相关的运动蛋白在SGs动态变化中发挥作用。在本文中，我们将讨论当前研究微管和分子微管马达在SGs组装、聚结、运动、组成、组织和分解中的功能的文献。
