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针对 HIV 组装的抗病毒靶向的新方法。

New approaches for antiviral targeting of HIV assembly.

机构信息

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35216, USA.

出版信息

J Mol Biol. 2011 Jul 22;410(4):634-40. doi: 10.1016/j.jmb.2011.03.074.

Abstract

The pressing need to develop antivirals active against resistant strains of HIV-1 has led to efforts to target steps in the virus life cycle other than reverse transcription and Gag proteolysis. Among those steps are entry, integration, and assembly and/or maturation. Advances in understanding the structural biology of both the immature and the mature forms of the HIV capsid have made it possible to design or discover small molecules and peptides that interfere with both assembly and maturation. Here, we review the current state of the art in assembly and maturation inhibitors.

摘要

开发针对 HIV-1 耐药株的抗病毒药物的迫切需求促使人们将目标转向病毒生命周期中除逆转录和 Gag 蛋白水解以外的步骤。这些步骤包括进入、整合、组装和/或成熟。对 HIV 衣壳不成熟和成熟形式的结构生物学的深入了解,使得设计或发现能够干扰组装和成熟的小分子和肽成为可能。本文综述了目前在组装和成熟抑制剂方面的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc8a/3139149/d674c02a3411/nihms-290529-f0001.jpg

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