针对 HIV 组装的抗病毒靶向的新方法。
New approaches for antiviral targeting of HIV assembly.
机构信息
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35216, USA.
出版信息
J Mol Biol. 2011 Jul 22;410(4):634-40. doi: 10.1016/j.jmb.2011.03.074.
Abstract
The pressing need to develop antivirals active against resistant strains of HIV-1 has led to efforts to target steps in the virus life cycle other than reverse transcription and Gag proteolysis. Among those steps are entry, integration, and assembly and/or maturation. Advances in understanding the structural biology of both the immature and the mature forms of the HIV capsid have made it possible to design or discover small molecules and peptides that interfere with both assembly and maturation. Here, we review the current state of the art in assembly and maturation inhibitors.
摘要
开发针对 HIV-1 耐药株的抗病毒药物的迫切需求促使人们将目标转向病毒生命周期中除逆转录和 Gag 蛋白水解以外的步骤。这些步骤包括进入、整合、组装和/或成熟。对 HIV 衣壳不成熟和成熟形式的结构生物学的深入了解，使得设计或发现能够干扰组装和成熟的小分子和肽成为可能。本文综述了目前在组装和成熟抑制剂方面的最新进展。
相似文献
1
New approaches for antiviral targeting of HIV assembly.针对 HIV 组装的抗病毒靶向的新方法。
J Mol Biol. 2011 Jul 22;410(4):634-40. doi: 10.1016/j.jmb.2011.03.074.
2
HIV-1 Maturation: Lessons Learned from Inhibitors.HIV-1 成熟：抑制剂带来的启示。
Viruses. 2020 Aug 26;12(9):940. doi: 10.3390/v12090940.
3
Inhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein.通过小分子靶向病毒衣壳蛋白的氨基末端结构域抑制HIV-1成熟
J Virol. 2017 Apr 13;91(9). doi: 10.1128/JVI.02155-16. Print 2017 May 1.
4
The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly.人类免疫缺陷病毒的衣壳蛋白：设计衣壳组装抑制剂
FEBS J. 2009 Nov;276(21):6110-7. doi: 10.1111/j.1742-4658.2009.07314.x.
5
Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain.α-螺旋订书肽设计来源于 HIV-1 衣壳二聚化结构域的抗病毒活性。
Retrovirology. 2011 May 3;8:28. doi: 10.1186/1742-4690-8-28.
6
HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors.作为抗病毒靶点的HIV-1 Gag：组装和成熟抑制剂的研发
Curr Top Med Chem. 2016;16(10):1154-66. doi: 10.2174/1568026615666150902102143.
7
Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.发现同时靶向HIV-1衣壳和人亲环素A的双重抑制剂以抑制病毒衣壳的组装和解聚。
Bioorg Med Chem. 2009 Apr 15;17(8):3177-88. doi: 10.1016/j.bmc.2009.02.051. Epub 2009 Mar 3.
8
Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation.鉴定 HIV-1 Gag 中一个病毒颗粒组装和成熟所必需的结构元件。
mBio. 2018 Oct 16;9(5):e01567-18. doi: 10.1128/mBio.01567-18.
9
HIV-1 Capsid Inhibitors as Antiretroviral Agents.作为抗逆转录病毒药物的HIV-1衣壳抑制剂
Curr HIV Res. 2016;14(3):270-82. doi: 10.2174/1570162x14999160224103555.
10
Resistance to Second-Generation HIV-1 Maturation Inhibitors.对第二代 HIV-1 成熟抑制剂的耐药性。
J Virol. 2019 Mar 5;93(6). doi: 10.1128/JVI.02017-18. Print 2019 Mar 15.
引用本文的文献
1
Antiviral Agents: Structural Basis of Action and Rational Design.抗病毒药物：作用的结构基础与合理设计
Subcell Biochem. 2024;105:745-784. doi: 10.1007/978-3-031-65187-8_20.
2
Molecular Determinants of Human Rhinovirus Infection, Assembly, and Conformational Stability at Capsid Protein Interfaces.人鼻病毒感染、组装和衣壳蛋白界面构象稳定性的分子决定因素。
J Virol. 2022 Dec 14;96(23):e0084022. doi: 10.1128/jvi.00840-22. Epub 2022 Nov 14.
3
Antiviral compounds modulate elasticity, strength and material fatigue of a virus capsid framework.抗病毒化合物调节病毒衣壳框架的弹性、强度和材料疲劳。
Biophys J. 2022 Mar 15;121(6):919-931. doi: 10.1016/j.bpj.2022.02.014. Epub 2022 Feb 11.
4
Virus Assembly Pathways: Straying Away but Not Too Far.病毒组装途径：偏离但不太远。
Small. 2020 Dec;16(51):e2004475. doi: 10.1002/smll.202004475. Epub 2020 Nov 25.
5
HIV Capsid Inhibitors Beyond PF74.除PF74之外的HIV衣壳抑制剂。
Diseases. 2019 Oct 30;7(4):56. doi: 10.3390/diseases7040056.
6
GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds.GS-CA化合物：覆盖多方面的一流HIV-1衣壳抑制剂
Front Microbiol. 2019 Jun 20;10:1227. doi: 10.3389/fmicb.2019.01227. eCollection 2019.
7
Evolution of Intermediates during Capsid Assembly of Hepatitis B Virus with Phenylpropenamide-Based Antivirals.基于苯丙烯酰胺的抗病毒药物作用下乙型肝炎病毒衣壳组装过程中中间体的演变
ACS Infect Dis. 2019 May 10;5(5):769-777. doi: 10.1021/acsinfecdis.8b00290. Epub 2019 Feb 4.
8
Characterization of Virus Capsids and Their Assembly Intermediates by Multicycle Resistive-Pulse Sensing with Four Pores in Series.采用串联四孔多循环电阻脉冲传感技术对病毒衣壳及其组装中间体进行表征。
Anal Chem. 2018 Jun 19;90(12):7267-7274. doi: 10.1021/acs.analchem.8b00452. Epub 2018 May 29.
9
Nanofluidic Devices with 8 Pores in Series for Real-Time, Resistive-Pulse Analysis of Hepatitis B Virus Capsid Assembly.串联 8 孔纳米流控装置，实时、电阻脉冲分析乙型肝炎病毒衣壳组装。
Anal Chem. 2017 May 2;89(9):4855-4862. doi: 10.1021/acs.analchem.6b04491. Epub 2017 Apr 17.
10
Virus Matryoshka: A Bacteriophage Particle-Guided Molecular Assembly Approach to a Monodisperse Model of the Immature Human Immunodeficiency Virus.病毒套娃：一种利用噬菌体颗粒引导的分子组装方法构建未成熟人类免疫缺陷病毒的单分散模型
Small. 2016 Nov;12(42):5862-5872. doi: 10.1002/smll.201601712. Epub 2016 Sep 16.
本文引用的文献
1
HIV capsid is a tractable target for small molecule therapeutic intervention.HIV 衣壳是小分子治疗干预的一个可行靶点。
PLoS Pathog. 2010 Dec 9;6(12):e1001220. doi: 10.1371/journal.ppat.1001220.
2
Virtual screening based identification of novel small-molecule inhibitors targeted to the HIV-1 capsid.基于虚拟筛选的 HIV-1 衣壳靶向新型小分子抑制剂的鉴定。
Bioorg Med Chem. 2011 Jan 1;19(1):77-90. doi: 10.1016/j.bmc.2010.11.045. Epub 2010 Nov 25.
3
Structural analysis of HIV-1 maturation using cryo-electron tomography.利用冷冻电镜断层成像术进行 HIV-1 成熟过程的结构分析。
PLoS Pathog. 2010 Nov 24;6(11):e1001215. doi: 10.1371/journal.ppat.1001215.
4
HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice.HIV-1 成熟抑制剂贝维利姆抑制不成熟的 Gag 晶格。
J Virol. 2011 Feb;85(4):1420-8. doi: 10.1128/JVI.01926-10. Epub 2010 Nov 24.
5
Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.发现了一系列抑制 HIV-1 衣壳组装的 1,5-二氢苯并[b][1,4]二氮杂环庚烷-2,4-二酮抑制剂。
Bioorg Med Chem Lett. 2011 Jan 1;21(1):398-404. doi: 10.1016/j.bmcl.2010.10.131. Epub 2010 Oct 31.
6
Hydrogen/deuterium exchange analysis of HIV-1 capsid assembly and maturation.HIV-1 衣壳组装和成熟的氢/氘交换分析。
Structure. 2010 Nov 10;18(11):1483-91. doi: 10.1016/j.str.2010.08.016.
7
Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization.小分子通过破坏病毒衣壳抑制人类免疫缺陷病毒 1 型感染。
J Virol. 2011 Jan;85(1):542-9. doi: 10.1128/JVI.01406-10. Epub 2010 Oct 20.
8
Structure and assembly of immature HIV.未成熟HIV的结构与组装
Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11090-5. doi: 10.1073/pnas.0903535106. Epub 2009 Jun 22.
9
X-ray structures of the hexameric building block of the HIV capsid.人类免疫缺陷病毒衣壳六聚体构建模块的X射线结构。
Cell. 2009 Jun 26;137(7):1282-92. doi: 10.1016/j.cell.2009.04.063. Epub 2009 Jun 11.
10
Susceptibility of human immunodeficiency virus type 1 to the maturation inhibitor bevirimat is modulated by baseline polymorphisms in Gag spacer peptide 1.1型人类免疫缺陷病毒对成熟抑制剂贝维拉马特的敏感性受Gag间隔肽1中基线多态性的调节。
Antimicrob Agents Chemother. 2009 May;53(5):2185-8. doi: 10.1128/AAC.01650-08. Epub 2009 Feb 17.
Zotero 插件