Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, People's Repulic of China.
Carbohydr Res. 2011 Sep 27;346(13):1903-8. doi: 10.1016/j.carres.2011.06.015. Epub 2011 Jul 15.
Eight new linear polyacetylene glucosides (1-8), containing two C(10)-, one C(13)- and five C(14)-acetylenes, together with three known polyacetylenes (9-11) were isolated from the florets of Carthamus tinctorius L. Their structures were elucidated by means of spectroscopic methods and chemical evidence. The absolute configurations of compounds 3-9 were confirmed by Snatzke and Gerards's method, observing the induced circular dichroism after addition of dirhodium tetrakis (trifluoroacetate) [Rh(2)(OCOCF(3))(4)] in CHCl(3). All the isolated compounds (1-11) were also tested for inhibitory activities against LPS-induced NO production in murine macrophages and just showed weak activities at concentrations of 1×10(-5)M.
从红花的小花中分离得到了 8 个新的线性聚乙炔葡萄糖苷（1-8），它们含有两个 C(10)-、一个 C(13)-和五个 C(14)-乙炔，以及三个已知的聚乙炔（9-11）。通过光谱方法和化学证据阐明了它们的结构。通过 Snatzke 和 Gerards 方法，观察到加入二钌四（三氟乙酸）[Rh(2)(OCOCF(3))(4)]后诱导的圆二色性，确定了化合物 3-9 的绝对构型。在 CHCl(3)中。所有分离得到的化合物（1-11）也都进行了对 LPS 诱导的 NO 产生的抑制活性测试，在 1×10(-5)M 的浓度下仅显示出较弱的活性。
