Department of Neurology, Chungnam National University Hospital, 640 Daesadong, Joonggu, 301-721 Daejeon, Republic of Korea.
Arch Gerontol Geriatr. 2012 Jul-Aug;55(1):70-2. doi: 10.1016/j.archger.2011.06.022. Epub 2011 Jul 16.
Decreased BMI has been reported that it may be associated with cognitive decline in the elderly. Weight loss is common in patients with PD. However, studies comparing cognitive changes according to BMI changes in PD have not been done yet. We performed this study to know a relationship between BMI changes and the rate of cognitive decline in PD. PD patients were recruited retrospectively. The patients (n=104) were divided into two groups according to BMI changes during initial 6 months of follow-up: decreased (n=52) vs. stable BMI groups (n=52). Cognitive functions were repeated until 36 months of follow-up using the Korean version of the Mini-Mental State Examination (K-MMSE) and the modified Mini-Mental State (3MS) test. We calculated the rate of cognitive decline (K-MMSE and 3MS score changes/month) and compared it between the two groups. The decreased BMI group showed lower level of cognitive function than that of stable BMI group, especially at the 36th month of follow-up (p<0.05). In addition, the rate of cognitive decline was also significantly faster in the decreased BMI group, particularly at the 36th month of follow-up (p<0.05). This study suggests that decreased BMI during initial 6 months of follow-up in PD might be a useful indicator for future risk of dementia and let clinicians predict faster rate of cognitive decline in patients with PD.
体重指数（BMI）降低与老年人认知能力下降有关已被报道。PD 患者常出现体重减轻。然而，目前尚未有研究比较 PD 患者 BMI 变化与认知变化之间的关系。我们进行这项研究是为了了解 PD 患者 BMI 变化与认知下降速度之间的关系。回顾性招募 PD 患者。根据最初 6 个月随访期间 BMI 的变化，将患者（n=104）分为两组：BMI 降低组（n=52）和稳定 BMI 组（n=52）。使用韩国版简易精神状态检查（K-MMSE）和改良简易精神状态检查（3MS）测试，在 36 个月的随访期间重复评估认知功能。我们计算认知下降率（K-MMSE 和 3MS 评分变化/月），并比较两组之间的差异。BMI 降低组的认知功能水平低于稳定 BMI 组，尤其是在 36 个月随访时（p<0.05）。此外，BMI 降低组的认知下降速度也明显较快，尤其是在 36 个月随访时（p<0.05）。这项研究表明，PD 患者最初 6 个月随访期间 BMI 降低可能是未来痴呆风险的有用指标，并能让临床医生预测 PD 患者认知下降速度更快。
