Institut de Biologie de l'Ecole Normale Supérieure, 46 rue d'Ulm, Paris, France.
Dev Cell. 2011 Jul 19;21(1):102-19. doi: 10.1016/j.devcel.2011.06.012.
The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the orientation of the axis of division and cell fate choices in classical models of asymmetric cell division. We then discuss the mechanisms of mitotic spindle orientation in symmetric cell divisions and its possible implications in tissue morphogenesis. Many recent studies show that future advances in the field of mitotic spindle orientation will arise from combinations of physical perturbation and modeling with classical genetics and developmental biology approaches.
有观点认为，有丝分裂纺锤体的取向控制着细胞命运的选择、组织架构和组织形态发生。在这里，我们综述了经典不对称细胞分裂模型中调节细胞分裂轴定向和细胞命运选择的机制。然后，我们讨论了对称细胞分裂中纺锤体定向的机制及其在组织形态发生中的可能意义。许多最近的研究表明，在有丝分裂纺锤体定向领域的未来进展将来自物理干扰与经典遗传学和发育生物学方法的结合。
