Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico.
Am J Obstet Gynecol. 2011 Sep;205(3):235.e15-24. doi: 10.1016/j.ajog.2011.04.019. Epub 2011 Apr 16.
The purpose of this study was to examine the histologic and immunologic differences between fetal membrane zones after membrane rupture at term delivery.
Fetal membrane explants from postrupture zones (periplacental, middle, rupture) were obtained from women following spontaneous vaginal delivery at term (n = 5). Tissues for histology, protein extracts, and RNA were isolated.
The collagen distribution decreased and the leukocyte density increased from the periplacental zone to the rupture zone. T cells were mainly present in the rupture zone and granulocytes in the middle zone. CXCL10, CXCR1, ICAM-1, -2, PSEL, tumor necrosis factor alpha, and matrix metalloproteinase-9 levels were higher in the middle zone than in the rupture zone and periplacental zone (P < .021). Interleukin-1beta and CXCL8 levels were higher in the rupture zone than in the middle zone and periplacental zone (P = .018 and P < .0001).
During labor specific immunologic microenvironments are created in the zones of the fetal membrane that may be involved in their rupture at the end of gestation.
本研究旨在探讨足月分娩胎膜破裂后胎膜各区域的组织学和免疫学差异。
本研究从自发性阴道分娩的足月产妇（n=5）的胎膜破裂后区域（胎盘旁、中部、破裂）获得胎膜组织。分离组织用于组织学、蛋白质提取物和 RNA。
胶原分布从胎盘旁区到破裂区减少，白细胞密度增加。T 细胞主要存在于破裂区，粒细胞存在于中部区。中间区的 CXCL10、CXCR1、ICAM-1、-2、PSEL、肿瘤坏死因子-α和基质金属蛋白酶-9 水平高于破裂区和胎盘旁区（P<.021）。破裂区的白细胞介素-1β和 CXCL8 水平高于中间区和胎盘旁区（P=0.018 和 P<.0001）。
在分娩过程中，胎膜的各个区域会形成特定的免疫微环境，这可能与妊娠末期胎膜破裂有关。
Zotero 插件