Department of Functional Materials in Medicine and Dentistry, University of Würzburg, D-97070 Würzburg, Germany.
Acta Biomater. 2011 Nov;7(11):4064-70. doi: 10.1016/j.actbio.2011.06.049. Epub 2011 Jul 1.
There is a current need for the localised delivery of antibiotics in order to treat implant-based bacterial infections. Existing treatments use non-resorbable materials such as poly(methyl methacrylate) beads loaded with antibiotics; unfortunately, as they are not resorbable, these beads require secondary surgery for removal. Calcium phosphate cements have considerable potential for the localised delivery of drugs since they can be resorbed to some extent within the body, eliminating the need for a secondary surgical procedure. Therefore, in this study, the efficacy of both hydroxyapatite and brushite cements in the delivery of silver ions has been investigated. The activity of the Ag(+) released from the cements was assessed against the growth of both Staphylococcus aureus and Staphylococcus epidermidis; the brushite cement exhibited excellent antibacterial properties and also showed an increase in compressive strength of over 30%. In this study we have found that with a few changes in Ag(+) concentration it should be possible to produce a fully resorbable bone replacement material that is combined with an antibacterial scaffold with controlled release over a period of time, which is likely to inhibit bacterial infections associated with implantation procedures.
目前需要局部递送抗生素来治疗基于植入物的细菌感染。现有的治疗方法使用非可吸收材料，如载有抗生素的聚甲基丙烯酸甲酯珠；然而，由于它们不可吸收，这些珠子需要进行二次手术取出。磷酸钙水泥在局部递药方面具有很大的潜力，因为它们在体内可以在一定程度上被吸收，从而无需进行二次手术。因此，在这项研究中，研究了羟基磷灰石和 Brushite 水泥在输送银离子方面的功效。评估了水泥释放的 Ag(+)对金黄色葡萄球菌和表皮葡萄球菌生长的抑制作用；Brushite 水泥表现出优异的抗菌性能，抗压强度也提高了 30%以上。在这项研究中，我们发现通过改变 Ag(+)浓度，应该有可能生产出一种完全可吸收的骨替代材料，该材料与具有控制释放功能的抗菌支架相结合，可以在一段时间内释放，这可能有助于抑制与植入物相关的细菌感染。
