Department for Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Veterinaerplatz 1, A-1210 Vienna, Austria.
Vet J. 2012 May;192(2):226-31. doi: 10.1016/j.tvjl.2011.06.026. Epub 2011 Jul 20.
Chronic kidney disease (CKD) may affect excretion and metabolism of vitamins but data for dogs are limited. In this study, blood vitamin levels were investigated in 19 dogs with chronic renal failure. High performance liquid chromatography was used to quantify retinol, retinyl esters, tocopherol, thiamine, riboflavin, pyridoxal-5'-phosphate, ascorbic acid and 25-hydroxycholecalciferol concentrations, whereas cobalamin, folate, biotin and pantothenic acid were measured by microbiological methods. Levels of retinol, retinyl palmitate, ascorbic acid, and vitamins B1, B2 and B6 were increased compared to healthy dogs. Dogs with CKD showed decreased concentrations of 25-hydroxycholecalciferol and folate. Alpha-tocopherol, biotin, pantothenate and cobalamin levels were not significantly different between controls and dogs with CKD. Whether lower vitamin D and folate concentrations in dogs with CKD justify supplementation has to be evaluated in future studies.
慢性肾脏病（CKD）可能会影响维生素的排泄和代谢，但有关犬类的资料有限。本研究调查了 19 只患有慢性肾衰竭的犬的血液维生素水平。采用高效液相色谱法定量检测视黄醇、视黄醇酯、生育酚、硫胺素、核黄素、吡哆醛-5'-磷酸、抗坏血酸和 25-羟胆钙化醇浓度，而钴胺素、叶酸、生物素和泛酸则采用微生物方法进行测量。与健康犬相比，犬的视黄醇、棕榈酸视黄醇、抗坏血酸以及维生素 B1、B2 和 B6 的水平升高。CKD 犬的 25-羟胆钙化醇和叶酸浓度降低。α-生育酚、生物素、泛酸和钴胺素水平在对照组和 CKD 犬之间无显著差异。在未来的研究中，需要评估 CKD 犬维生素 D 和叶酸浓度较低是否需要补充。
